ArticlePloS one2014
Hilar somatostatin interneurons contribute to synchronized GABA activity in an in vitro epilepsy model.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 15 citations in OpenAlex.
- Absence of GluN2A in hippocampal CA1 neurons leads to altered dendritic structure and reduced frequency of miniature excitatory synaptic events.Brain communications · 2025Article
- Dynamics of synaptic extracellular field potentials in the nucleus laminaris of the barn owl.Journal of neurophysiology · 2019Article
- The 4-Aminopyridine Model of Acute SeizuresFrontiers in neuroscience · 2019Article
- Article
- Somatostatin-expressing neurons in cortical networks.Nature reviews. Neuroscience · 2016Review
- Postnatal development of the electrophysiological properties of somatostatin interneurons in the anterior cingulate cortex of mice.Scientific reports · 2016Article
- Ectopic Expression of α6 and δ GABAA Receptor Subunits in Hilar Somatostatin Neurons Increases Tonic Inhibition and Alters Network Activity in the Dentate Gyrus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Step-by-step instructions for retina recordings with perforated multi electrode arrays.PloS one · 2014Article
- Network Properties Revealed during Multi-Scale Calcium Imaging of Seizure Activity in Zebrafish.eNeuroArticle
- Article
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
Epilepsy is a disorder characterized by excessive synchronized neural activity. The hippocampus and surrounding temporal lobe structures appear particularly sensitive to epileptiform activity. Somatostatin (SST)-positive interneurons within the hilar region have been suggested to gate hippocampal activity, and therefore may play a crucial role in the dysregulation of hippocampal activity. In this study, we examined SST interneuron activity in the in vitro 4-aminopyridine (4-AP) model of epilepsy. We employed a multi-disciplinary approach, combining extracellular multi-electrode array (MEA) recordings with patch-clamp recordings and optical imaging using a genetically encoded calcium sensor. We observed that hilar SST interneurons are strongly synchronized during 4-AP-induced local field potentials (LFPs), as assayed by Ca(2+) imaging as well as juxtacellular or intracellular recording. SST interneurons were particularly responsive to GABA-mediated LFPs that occurred in the absence of ionotropic glutamatergic transmission. Our results present evidence that the extensive synchronized activity of SST-expressing interneurons contribute to the generation of GABAergic LFPs in an in vitro model of temporal lobe seizures.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.