ArticlePloS one2014
Reference intervals for serum cystatin C and factors influencing cystatin C levels other than renal function in the elderly.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 25 citations in OpenAlex.
- Hepatorenal Syndrome-Novel Insights into Diagnostics and Treatment.International journal of molecular sciences · 2023Review
- Age-adjusted reference values and influencing factors of cystatin C in healthy Chinese population.International urology and nephrology · 2023Article
- Article
- Reference intervals for serum cystatin C in neonates and children 30 days to 18 years old.Pediatric nephrology (Berlin, Germany) · 2020Observational
- Prevalence and determinants of differences in cystatin C and creatinine-based estimated glomerular filtration rate in community-dwelling older adults: a cross-sectional study.BMC nephrology · 2017Article
- CKD-EPI creatinine-cystatin C glomerular filtration rate estimation equation seems more suitable for Chinese patients with chronic kidney disease than other equations.BMC nephrology · 2017Article
- Modification of the 2012 CKD-EPI equations for the elderly Chinese.International urology and nephrology · 2017Article
- Development of a Competitive Cystatin C-Specific Bioassay Suitable for Repetitive Measurements.PloS one · 2016Article
- Chronic kidney disease screening methods and its implication for Malaysia: an in depth review.Global journal of health science · 2015Review
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe present study aimed to establish reference intervals for serum cystatin C (Scys-C) stratified by stages of chronic kidney disease, explore factors influencing Scys-C and compare the performance of Scys-C with serum creatinine (Scr) in the young and elderly.
methodsA total of 800 participants, 516 young (<60 years) and 284 old (≥60 years) subjects were included in this study. Scys-C and Scr were assayed by the partical-enhanced immunoturbidimetry method and enzymatic method respectively. 95% reference interval was adopted to evaluate reference intervals. Influencing factors were characterized by multivariate linear regression analysis. Relationship between reference glomerular filtration rate (rGFR) and Scys-C or Scr was determined by correlation coefficient.
resultsReference intervals for Scys-C were calculated to be 0.71-1.38 mg/L, 0.83-1.67 mg/L, 1.02-2.61 mg/L, 1.32-4.48 mg/L, 1.95-6.11 mg/L in the aged in CKD G1, G2, G3a, G3b and G4-5 stages, respectively. Body mass index(BMI), nephritis, kidney neoplasm and hypertension were demonstrated as factors affecting Scys-C in the elderly while gender, nephritis and kidney neoplasm were clarified as influencing factors in the young group. Scr levels were affected by more factors, such as body surface area and hematological disease. Correlation coefficient between rGFR and Scys-C or Scr showed that serum Scys-C was superior to Scr, especially in the subjects with mildly decreased renal function (-0.593 vs. -0.520).
conclusionsFactors other than renal function influenced Scys-C when applying to evaluate glomerular filtration rate (GFR), such as BMI, nephritis, kidney neoplasm and hypertension, and Scys-C had higher correlation with GFR than Scr in the elderly.
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