Evidence map›Paper›PMID 24465811›Full record

ArticlePloS one2014

A prospective study: current problems in radiotherapy for nasopharyngeal carcinoma in yogyakarta, indonesia.

Sharon D Stoker, Maarten A Wildeman, Renske Fles, Sagung R Indrasari, Camelia Herdini, Pieter L Wildeman, Judi N A van Diessen, Maesadji Tjokronagoro, I Bing Tan

Open access · goldAbstract read
In one paragraph

Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.6field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Sharon D StokerDepartment of head and neck oncology and Surgery, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Maarten A WildemanDepartment of head and neck oncology and Surgery, The Netherlands Cancer Institute, Amsterdam, The Netherlands ; Department of otorhinolaryngology, Academic Medical Centre, Amsterdam, the Netherlands.
Renske FlesDepartment of head and neck oncology and Surgery, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Sagung R IndrasariDepartment of otorhinolaryngology, Dr Sardjito General Hospital/Faculty of Medicine Universitas Gadjah Mada, Yogyakarta, Indonesia.
Camelia HerdiniDepartment of otorhinolaryngology, Dr Sardjito General Hospital/Faculty of Medicine Universitas Gadjah Mada, Yogyakarta, Indonesia.
Pieter L WildemanValueCare BV, Utrecht, The Netherlands.
Judi N A van DiessenDepartment of radiation and oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Maesadji TjokronagoroDepartment of radiotherapy, Dr Sardjito General Hospital/Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia.
I Bing TanDepartment of head and neck oncology and Surgery, The Netherlands Cancer Institute, Amsterdam, The Netherlands ; Department of otorhinolaryngology, Academic Medical Centre, Amsterdam, the Netherlands ; Department of oral and maxillofacial surgery, Academic Medical Centre, Amsterdam, the Netherlands.
The Netherlands Cancer Institute · NLUniversitas Gadjah Mada · IDAcademic Medical Center · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionNasopharyngeal carcinoma (NPC) has a high incidence in Indonesia. Previous study in Yogyakarta revealed a complete response of 29% and a median overall survival of less than 2 years. These poor treatment outcome are influenced by the long diagnose-to-treatment interval to radiotherapy (DTI) and the extended overall treatment time of radiotherapy (OTT). This study reveals insight why the OTT and DTI are prolonged.

methodAll patients treated with curative intent radiotherapy for NPC between July 2011 until October 2012 were included. During radiotherapy a daily diary was kept, containing information on DTI, missed radiotherapy days, the reason for missing and length of OTT.

resultsSixty-eight patients were included. The median DTI was 106 days (95% CI: 98-170). Fifty-nine patients (87%) finished the treatment. The median OTT for radiotherapy was 57 days (95% CI: 57-65). The main reason for missing days was an inoperative radiotherapy machine (36%). Other reasons were patient's poor condition (21%), public holidays (14%), adjustment of the radiation field (7%), power blackout (3%), inoperative treatment planning system (2%) and patient related reasons (9%). Patient's insurance type was correlated to DTI in disadvantage for poor people.

conclusionYogyakarta has a lack of sufficient radiotherapy units which causes a delay of 3-4 months, besides the OTT is extended by 10-12 days. This influences treatment outcome to a great extend. The best solution would be creating sufficient radiotherapy units and better management in health care for poor patients. The growing economy in Indonesia will expectantly in time enable these solutions, but in the meantime solutions are needed. Solutions can consist of radiation outside office hours, better maintenance of the facilities and more effort from patient, doctor and nurse to finish treatment in time. These results are valuable when improving cancer care in low and middle income countries.

Indexed as

AdolescentAdultAgedAged, 80 and overCarcinomaChildDose Fractionation, RadiationFemaleHumansIndonesiaMaleMiddle AgedNasopharyngeal CarcinomaNasopharyngeal NeoplasmsProspective StudiesTreatment Outcome

Identifiers

PMID24465811
PMCPMC3900459
OpenAlexW2062280907

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.