ArticlePloS one2014
Spatially reciprocal inhibition of inhibition within a stimulus selection network in the avian midbrain.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Evolutionarily old brainstem neurons are required for the control of selective spatial attention.Nature communications · 2026Article
- The dynamics of stimulus selection in the nucleus isthmi pars magnocellularis of avian midbrain network.Scientific reports · 2025Article
- Distinct neural mechanisms construct classical versus extraclassical inhibitory surrounds in an inhibitory nucleus in the midbrain attention network.Nature communications · 2023Article
- Donut-like organization of inhibition underlies categorical neural responses in the midbrain.Nature communications · 2022Article
- Unraveling circuits of visual perception and cognition through the superior colliculus.Neuron · 2021Review
- Article
- Categorical Signaling of the Strongest Stimulus by an Inhibitory Midbrain Nucleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Spatial Dependence of Stimulus Competition in the Avian Nucleus Isthmi Pars Magnocellularis.Brain, behavior and evolution · 2019Article
- Neural Circuits That Mediate Selective Attention: A Comparative Perspective.Trends in neurosciences · 2018Review
- Circuits for Action and Cognition: A View from the Superior Colliculus.Annual review of vision science · 2017Review
- A choice motif.eLife · 2016Article
- Descending control of neural bias and selectivity in a spatial attention network: rules and mechanisms.Neuron · 2014Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Reciprocal inhibition between inhibitory projection neurons has been proposed as the most efficient circuit motif to achieve the flexible selection of one stimulus among competing alternatives. However, whether such a motif exists in networks that mediate selection is unclear. Here, we study the connectivity within the nucleus isthmi pars magnocellularis (Imc), a GABAergic nucleus that mediates competitive selection in the midbrain stimulus selection network. Using laser photostimulation of caged glutamate, we find that feedback inhibitory connectivity is global within the Imc. Unlike typical lateral inhibition in other circuits, intra-Imc inhibition remains functionally powerful over long distances. Anatomically, we observed long-range axonal projections and retrograde somatic labeling from focal injections of bi-directional tracers in the Imc, consistent with spatial reciprocity of intra-Imc inhibition. Together, the data indicate that spatially reciprocal inhibition of inhibition occurs throughout the Imc. Thus, the midbrain selection circuit possesses the most efficient circuit motif possible for fast, reliable, and flexible selection.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.