SynthesisPloS one2014
Retinal nerve fiber layer thickness changes in Parkinson disease: a meta-analysis.
Synthesis in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01928212 (Retinal Nerve Fiber Layer Thickness Changes in Parkinson Disease), which is not on this map. Cited by 93 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Retinal Nerve Fiber Layer Thickness Changes in Parkinson Disease: A Meta-analysis
Who cites it
93 citing papers in PubMed, 5 syntheses or guidelines pooled it, 189 citations in OpenAlex.
- Amyotrophic lateral sclerosis and retinal changes in optical coherence tomography: A systematic review and meta-analysis.Brain and behavior · 2022Pooled it
- The specific pattern of retinal nerve fiber layer thinning in Parkinson's disease: a systematic review and meta-analysis.Journal of neurology · 2021Pooled it
- Retinal nerve fiber layer changes in migraine: a systematic review and meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021Pooled it
- Pooled it
- Pooled it
- Retinal Neurovascular and Mitochondrial Function Signatures in Response to a 24-Week Yoga Intervention in Healthy Adults.Investigative ophthalmology & visual science · 2025Trial
- Functional and morphological assessment of ocular structures and follow-up of patients with early-stage Parkinson's disease.International ophthalmology · 2019Trial
- Trial
- Retinal Architecture in Parkinson's Disease with Rapid Eye Movement Sleep Behaviour Disorder: Insights from a Scoping Review.Annals of neurosciences · 2026Review
- OCT-based optic neuropathy diagnosis using explainable and privacy-preserving machine learning.Scientific reports · 2026Article
- Multiple attention based deep multimodal fusion network for glaucoma and neurodegenerative disease diagnosis.Scientific reports · 2026Article
- The Retinal Age Gap as a Marker of Accelerated Aging in the Early Course of Schizophrenia.Schizophrenia bulletin · 2026Article
- Structural changes in the retinal layers of patients with Steinert disease.Frontiers in ophthalmology · 2026Article
- Altered Neuroretinal Tissue in Childhood Cancer Survivors: Data From the German CVSS Study.Translational vision science & technology · 2025Article
- Pupillographic evaluation accompanying structural and functional assessment of the optic nerve in patients with Parkinson's disease.BMC ophthalmology · 2025Article
- Retinal Thickness in Patients with Parkinson's Disease and Dopa Responsive Dystonia-Is There Any Difference?Biomedicines · 2025Article
- Keeping an eye on Parkinson's disease: color vision and outer retinal thickness as simple and non-invasive biomarkers.Journal of neurology · 2025Review
- Analysis of macular retinal thickness in polyarteritis nodosa using spectral domain optical coherence tomography.Journal of ophthalmic inflammation and infection · 2025Article
- Idiopathic Parkinson's Disease and Neuro-ophthalmological Findings: A Study on Neurodegeneration in the Retinal Nerve Fiber Layer and Cognitive Functions.Noro psikiyatri arsivi · 2025Article
- Changes in Visual Evoked Potential and Optical Coherence Tomography in Parkinson's Disease: A Systematic Review and Meta-Analysis.Parkinson's disease · 2025Review
33 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundParkinson disease (PD) is a neurodegenerative process that leads to a selective loss of dopaminergic neurons, mainly in the basal ganglia of the brain. Numerous studies have analyzed the ability of optical coherence tomography (OCT) to detect retinal nerve fiber layer (RNFL) thickness abnormalities and changes in PD, but the results have not always been consistent. Therefore, we carried out a meta-analysis to evaluate the RNFL thickness measured with OCT in PD. METHODS AND
findingsCase-control studies were selected through an electronic search of the Cochrane Controlled Trials Register, PUBMED and EMBASE. For the continuous outcomes, we calculated the weighted mean difference (WMD) and 95% confidence interval (CI). The statistical analysis was performed by RevMan 5.0 software. Thirteen case-control studies were included in the present meta-analysis, containing a total of 644 eyes in PD patients and 604 eyes in healthy controls. The results of our study showed that there was a significant reduction in average RNFL thickness in patients with PD compared to healthy controls (WMD = -5.76, 95% CI: -8.99 to -2.53, P = 0.0005). Additionally, differences of RNFL thickness in superior quadrant (WMD = -4.44, 95% CI: -6.93 to -1.94, P = 0.0005), inferior quadrant (WMD = -7.56, 95% CI: -11.33 to -3.78, P<0.0001), nasal quadrant (WMD = -3.12, 95% CI: -5.63 to -0.61, P = 0.01) and temporal quadrant (WMD = -4.63, 95% CI: -7.20 to -2.06, P = 0.0004) were all significant between the two groups.
conclusionIn view of these results and the noninvasive nature of OCT technology, we surmise that OCT could be a useful tool for evaluating the progression of the Parkinson disease.
trial registrationClinicalTrials.gov NCT01928212.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.