ArticlePloS one2014
Bacillus pumilus reveals a remarkably high resistance to hydrogen peroxide provoked oxidative stress.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It carries an expression of concern. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 36 citations in OpenAlex.
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- Microbial load of heritage dermatological moulages of the historic university department in Wroclaw, Poland.Postepy dermatologii i alergologii · 2023Article
- Cutaneous Microbiome Profiles Following Chlorhexidine Treatment in a 72-Hour Daily Follow-Up Paired Design: a Pilot Study.Microbiology spectrum · 2022Article
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- SigB-regulated antioxidant functions in gram-positive bacteria.World journal of microbiology & biotechnology · 2021Review
- Alteration of Proteomes in First-Generation Cultures of Bacillus pumilus Spores Exposed to Outer Space.mSystems · 2019Article
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- Physiological Studies ofmBio · 2018Article
- Disarming Fungal Pathogens:mBio · 2017Article
- Transcriptome profiling analysis reveals metabolic changes across various growth phases in Bacillus pumilus BA06.BMC microbiology · 2017Article
- Bacillus pumilus KatX2 confers enhanced hydrogen peroxide resistance to a Bacillus subtilis PkatA::katX2 mutant strain.Microbial cell factories · 2017Article
- Heterologous expression and characterization of a new heme-catalase in Bacillus subtilis 168.Journal of industrial microbiology & biotechnology · 2016Article
- Physiological roles of bacillithiol in intracellular metal processing.Current genetics · 2016Review
- Article
- Bacillithiol has a role in Fe-S cluster biogenesis in Staphylococcus aureus.Molecular microbiology · 2015Article
- Antibacterial metabolites and bacteriolytic enzymes produced by Bacillus pumilus during bacteriolysis of Arthrobacter citreus.Marine biotechnology (New York, N.Y.) · 2015Article
- Effects of actin-like proteins encoded by two Bacillus pumilus phages on unstable lysogeny, revealed by genomic analysis.Applied and environmental microbiology · 2015Article
- Redox regulation by reversible protein S-thiolation in bacteria.Frontiers in microbiology · 2015Review
- Expression of concern: Bacillus pumilus reveals a remarkably high resistance to hydrogen peroxide provoked oxidative stress.PloS one · 2014Article
Corrections and comments
- Expression of concern
Authors and funding
13 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bacillus pumilus is characterized by a higher oxidative stress resistance than other comparable industrially relevant Bacilli such as B. subtilis or B. licheniformis. In this study the response of B. pumilus to oxidative stress was investigated during a treatment with high concentrations of hydrogen peroxide at the proteome, transcriptome and metabolome level. Genes/proteins belonging to regulons, which are known to have important functions in the oxidative stress response of other organisms, were found to be upregulated, such as the Fur, Spx, SOS or CtsR regulon. Strikingly, parts of the fundamental PerR regulon responding to peroxide stress in B. subtilis are not encoded in the B. pumilus genome. Thus, B. pumilus misses the catalase KatA, the DNA-protection protein MrgA or the alkyl hydroperoxide reductase AhpCF. Data of this study suggests that the catalase KatX2 takes over the function of the missing KatA in the oxidative stress response of B. pumilus. The genome-wide expression analysis revealed an induction of bacillithiol (Cys-GlcN-malate, BSH) relevant genes. An analysis of the intracellular metabolites detected high intracellular levels of this protective metabolite, which indicates the importance of bacillithiol in the peroxide stress resistance of B. pumilus.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.