ArticlePloS one2014
Influences of COMT and 5-HTTLPR polymorphisms on cognitive flexibility in healthy women: inhibition of prepotent responses and memory updating.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed.
- Genetic Inactivation of the Serotonin Transporter Dysregulates Expression of Neurotransmission Genes and Genome-Wide DNA Methylation Levels in the Medial Prefrontal Cortex of Male Rats During Postnatal Development.Developmental neurobiology · 2025Article
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- Unaffected Memory and Inhibitory Functioning Several Weeks Postpartum in Women with Pregnancy Complicated by Preeclampsia.Behavioral sciences (Basel, Switzerland) · 2021Article
- The "Warrior" COMT Val/Met Genotype Occurs in Greater Frequencies in Mixed Martial Arts Fighters Relative to Controls.Journal of sports science & medicine · 2020Article
- EEG Source Imaging Indices of Cognitive Control Show Associations with Dopamine System Genes.Brain topography · 2018Article
- Age-related differences in inhibitory control and memory updating in boys with Asperger syndrome.European archives of psychiatry and clinical neuroscience · 2017Article
- Association between the serotonin transporter gene polymorphism and verbal learning in older adults is moderated by gender.Translational psychiatry · 2017Article
- Serotonin Transporter Genetic Variation is Differentially Associated with Reflexive- and Reflective-Optimal Learning.Cerebral cortex (New York, N.Y. : 1991) · 2017Article
- Does Prenatal Valproate Interact with a Genetic Reduction in the Serotonin Transporter? A Rat Study on Anxiety and Cognition.Frontiers in neuroscience · 2016Article
- Genetic variation in the serotonin transporter gene influences ERP old/new effects during recognition memory.Neuropsychologia · 2015Article
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9 authors.
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Abstract
Understanding genetic factors that affect monoamine neurotransmitters flux in prefrontal cortex may help to further specify the complex neurobiological processes that underlie cognitive function and dysfunction in health and illness. The current study examined the associations between the polymorphisms of dopaminergic (COMT Met158Val) and serotoninergic (5-HTTLPR) genes and the sequential pattern of responses in a motor random generation task providing well-established indexes for executive functioning in a large sample of 255 healthy women. Participants homozygous for the Met allele of the COMT polymorphism showed impaired inhibition of prepotent responses, whereas individuals homozygous for the s-allele of the 5-HTTLPR showed a restricted ability to update information in working memory. Taken together the results indicate differentiated influences of dopaminergic and serotonergic genes on important and definite executive sub-processes related to cognitive flexibility.
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