Evidence map›Paper›PMID 24465558›Full record

ArticlePloS one2014

High-risk cervical human papillomavirus infections among human immunodeficiency virus-positive women in the Bahamas.

Dionne N Dames, Elizabeth Blackman, Raleigh Butler, Emanuela Taioli, Stacy Eckstein, Karthik Devarajan, Andrea Griffith-Bowe, Perry Gomez, Camille Ragin, African Caribbean Cancer Consortium

Open access · goldAbstract read
In one paragraph

Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 3 pooled it
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 3 syntheses or guidelines pooled it, 26 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Dionne N DamesDepartment of Medicine, Princess Margaret Hospital, Nassau, Bahamas.
Elizabeth BlackmanCancer Prevention and Control Program, Fox Chase Cancer Center - Temple University Health System, Philadelphia, PA, USA.
Raleigh ButlerDepartment of Obstetrics & Gynecology, Princess Margaret Hospital, Nassau, Bahamas.
Emanuela TaioliDepartment of Population Health, North Shore Long Island Jewish/Hofstra School of Medicine, Manhasset, NY, USA.
Stacy EcksteinDepartment of Epidemiology, University of Pittsburgh, Graduate School of Public Health and the University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA.
Karthik DevarajanDepartment of Biostatistics, Fox Chase Cancer Center, Philadelphia, PA, USA.
Andrea Griffith-BoweDepartment of Obstetrics & Gynecology, Princess Margaret Hospital, Nassau, Bahamas.
Perry GomezDepartment of Medicine, Princess Margaret Hospital, Nassau, Bahamas.
Camille RaginCancer Prevention and Control Program, Fox Chase Cancer Center - Temple University Health System, Philadelphia, PA, USA.
African Caribbean Cancer Consortium
Fox Chase Cancer Center · USCollege of The Bahamas · BSIJ Research (United States) · USUPMC Hillman Cancer Center · US

Funding

WORD PROCESSING CENTER--COREP30CA006927 · NCI · RESEARCH INST OF FOX CHASE CAN CTR · PI Margaret von Mehren · 1985 to 2026
$138.8M
Priority StageP20CA132385 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SOBOL, ROBERT W · 2007 to 2009
$465k
Afro-Caribbean Consortium on viral and environmental risk factors for cancerR13CA130596 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI RAGIN, CAMILLE C · 2007 to 2007
$3k
NCI NIH HHS CA006927NCI NIH HHS P20 CA132385NCI NIH HHS P20CA132385-01NCI NIH HHS P30 CA006927NCI NIH HHS R13 CA130596NCI NIH HHS R13CA130596A
6 · The paper itself

Abstract

backgroundHigh-risk (HR) HPV genotypes other than 16 and 18 have been detected in a significant proportion of immunocompromised females. We aim to evaluate the frequency of HR HPV genotypes in a population of HIV-positive Caribbean women.

methodsOne hundred sixty-seven consecutive, non-pregnant, HIV-positive females ≥18 years were recruited in this study. Each participant received a vaginal examination, PAP smear, and completed a questionnaire. DNA was extracted for HPV testing in 86 patients.

resultsMean age was 39.1 years for women positive for HR HPV and 43.1 years for women negative for HR HPV (P value  = 0.040). 78% (130/167) of the women had HR HPV infections; the prevalence of abnormal cervical cytology was 38% among women who were HR HPV-positive compared to women who were HR HPV-negative (22%). Fifty-one percent of the 86 women with available genotype carried infections with HPV 16 and/or HPV 18; genotypes of unknown risk were also frequently observed. Women who had a CD4+ count of ≤200 had 7 times increased odds of carrying HR HPV infection in comparison to women with CD4+>200.

conclusionsHR HPV infections in HIV infected females may consist of more than just HPV 16 and 18, but also HPV 52 and 58. Further studies are needed to determine whether HPV 52 and 58 play a significant role in the development of cervical cytological abnormalities in HIV+ women.

Indexed as

AdultAgedBahamasCervix UteriCoinfectionFemaleGenotypeHIV InfectionsHuman papillomavirus 16Human papillomavirus 18HumansMiddle AgedPapillomavirus InfectionsPrevalenceRiskUterine Cervical Neoplasms

Identifiers

PMID24465558
PMCPMC3900425
OpenAlexW2018723687

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.