Evidence map›Paper›PMID 24465531›Full record

ArticlePloS one2014

Divergent Wnt8a gene expression in teleosts.

Nesrin Mwafi, Carlo A Beretta, Alessio Paolini, Matthias Carl

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 89% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

  • Erratum issued
5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Nesrin MwafiHeidelberg University, Medical Faculty Mannheim, Department of Cell and Molecular Biology, Mannheim, Germany.
Carlo A BerettaHeidelberg University, Medical Faculty Mannheim, Department of Cell and Molecular Biology, Mannheim, Germany.
Alessio PaoliniHeidelberg University, Medical Faculty Mannheim, Department of Cell and Molecular Biology, Mannheim, Germany.
Matthias CarlHeidelberg University, Medical Faculty Mannheim, Department of Cell and Molecular Biology, Mannheim, Germany.
University Medical Centre Mannheim · DEUniversity Hospital Heidelberg · DE

Funding

Biotechnology and Biological Sciences Research Council BB/C51454X/1
6 · The paper itself

Abstract

The analysis of genes in evolutionarily distant but morphologically similar species is of major importance to unravel the changes in genomes over millions of years, which led to gene silencing and functional diversification. We report the analysis of Wnt8a gene expression in the medakafish and provide a detailed comparison to other vertebrates. In all teleosts analyzed there are two paralogous Wnt8a copies. These show largely overlapping expression in the early developing zebrafish embryo, an evolutionarily distant relative of medaka. In contrast to zebrafish, we find that both maternal and zygotic expression of particularly one Wnt8a paralog has diverged in medaka. While Wnt8a1 expression is mostly conserved at early embryonic stages, the expression of Wnt8a2 differs markedly. In addition, both genes are distinctly expressed during organogenesis unlike the zebrafish homologs, which may hint at the emergence of functional diversification of Wnt8a ligands during evolution.

Indexed as

AnimalsCytoskeletal ProteinsEmbryo, NonmammalianGene Expression Regulation, DevelopmentalOryziasWnt ProteinsZebrafishZebrafish ProteinsCytoskeletal Proteinswnt8a protein, zebrafishWnt ProteinsZebrafish Proteins

Identifiers

PMID24465531
PMCPMC3896364
OpenAlexW2094200778

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.