ArticlePloS one2014
The role of flotillins in regulating aβ production, investigated using flotillin 1-/-, flotillin 2-/- double knockout mice.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 31 citations in OpenAlex.
- Flotillins in membrane trafficking and physiopathology.Biology of the cell · 2025Review
- Flot2 acts as a novel mediator of podocyte injury in proteinuric kidney disease.International journal of biological sciences · 2023Article
- Anti-flotillin-1/2 antibodies in a patient with neurogenic muscle atrophy and mild neuropsychological impairment.Neurological research and practice · 2022Article
- Modeling the early stages of Alzheimer's disease by administering intracerebroventricular injections of human native Aβ oligomers to rats.Acta neuropathologica communications · 2022Article
- Article
- Flotillin-Dependent Membrane Microdomains Are Required for Functional Phagolysosomes against Fungal Infections.Cell reports · 2020Article
- Flotillin membrane domains in cancer.Cancer metastasis reviews · 2020Review
- Flotillin: A Promising Biomarker for Alzheimer's Disease.Journal of personalized medicine · 2020Review
- Flotillins: At the Intersection of ProteinInternational journal of molecular sciences · 2020Review
- Neurodegeneration and Neuro-Regeneration-Alzheimer's Disease and Stem Cell Therapy.International journal of molecular sciences · 2019Review
- The Flot2 component of the lipid raft changes localization during neural differentiation of P19C6 cells.BMC molecular and cell biology · 2019Article
- New Insights Into Immune Cell-Derived Extracellular Vesicles in Multiple Sclerosis.Frontiers in neurology · 2018Review
- Flotillin proteins recruit sphingosine to membranes and maintain cellular sphingosine-1-phosphate levels.PloS one · 2018Article
- A plasma membrane microdomain compartmentalizes ephrin-generated cAMP signals to prune developing retinal axon arbors.Nature communications · 2016Article
- Flotillin-1 facilitates toll-like receptor 3 signaling in human endothelial cells.Basic research in cardiology · 2014Article
- Roles of flotillins in tumors.Journal of Zhejiang University. Science. BReview
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Flotillin 1 and flotillin 2 associate in the plasma membrane to form microdomains that have roles in cell signaling, regulation of cell-cell contacts, membrane-cytoskeletal interactions, and endocytosis. They are thought to be involved in the trafficking and hence processing of the Amyloid Precursor Protein, APP. In this study we set out to obtain in vivo confirmation of a link between flotillins and cleavage of APP to release amyloidogenic Aβ peptide, and to generate tools that would allow us to ask whether flotillins are functionally redundant. We used a mouse model for Aβ-dependent cerebral amyloidosis, APPPS1 mice, combined with deletion of either flotillin 1 singly, or flotillin 1 and flotillin 2 together. There was a small but significant reduction in Aβ levels, and the abundance of congo-red stained plaques, in brains of 12 week old mice lacking flotillin 1. A similar reduction in Aβ levels was observed in the flotillin 1-/-, flotillin 2-/- double knockouts. We did not observe large effects on the clustering or endocytosis of APP in flotillin 1-/- mouse embryonic fibroblasts. We conclude that flotillins are likely to play some role in APP trafficking or processing, but the relevant cellular mechanisms require more investigation. The availability of flotillin 1-/-, flotillin 2-/- mice, which have no overt phenotypes, will facilitate research into flotillin function in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.