Evidence map›Paper›PMID 24465444›Full record

ArticlePloS one2014

A cluster randomized controlled trial evaluating the efficacy of peer mentors to support South African women living with HIV and their infants.

Mary Jane Rotheram-Borus, Linda M Richter, Alastair van Heerden, Heidi van Rooyen, Mark Tomlinson, Jessica M Harwood, W Scott Comulada, Alan Stein

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00972699 (Mentor Mothers), which is not on this map. Cited by 55 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed, 11 pooled it
9.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00972699 phase2completednot on this map

Mentor Mothers: A Sustainable Family Intervention in South African Townships

TypeinterventionalSponsorUniversity of California, Los AngelesRan2008 to 2011Enrolled1,200ConditionsHuman Immunodeficiency Virus, Acquired Immune Deficiency Syndrome, TuberculosisArmsPeer support and mentoring
3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 11 syntheses or guidelines pooled it, 81 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 3 countries.

Mary Jane Rotheram-BorusGlobal Center for Children and Families, University of California, Los Angeles, California, United States of America.
Linda M RichterDevelopmental Pathways to Health Research Unit, University of the Witwatersrand, Johannesburg, Gauteng, South Africa ; HIV/AIDS, STIs and TB, Human Sciences Research Council, Durban, KwaZulu-Natal, South Africa.
Alastair van HeerdenDevelopmental Pathways to Health Research Unit, University of the Witwatersrand, Johannesburg, Gauteng, South Africa.
Heidi van RooyenDevelopmental Pathways to Health Research Unit, University of the Witwatersrand, Johannesburg, Gauteng, South Africa.
Mark TomlinsonDepartment of Psychology, University of Stellenbosch, Matieland, South Africa.
Jessica M HarwoodGlobal Center for Children and Families, University of California, Los Angeles, California, United States of America.
W Scott ComuladaGlobal Center for Children and Families, University of California, Los Angeles, California, United States of America.
Alan SteinDepartment of Psychiatry, Oxford University, Oxford, United Kingdom.
University of the Witwatersrand · ZAFamilies USA · USCenter for Children · USStellenbosch University · ZAUniversity of Oxford · GB

Funding

UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
UCLA Rapid, Relevant, Rigorous Implementation Science HubP30MH058107 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI RAPHAEL J LANDOVITZ · 1997 to 2026
$53.5M
Virology CoreP30AI028697 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MITSUYASU, RONALD T. · 1991 to 2018
$39.9M
Mentor Mothers: A Sustainable Family Intervention in South African TownshipsR01MH077553 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ROTHERAM-BORUS, MARY JANE · 2006 to 2010
$3.5M
The Global Partnership for AIDS Behavioral Research: South Africa and U.S.R24AA022919 · NIAAA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ROTHERAM-BORUS, MARY JANE · 2013 to 2017
$2.4M
NCATS NIH HHS UL1 TR000124NCATS NIH HHS UL1TR000124NIAAA NIH HHS R24 AA022919NIAID NIH HHS P30 AI028697NIAID NIH HHS P30AI028697NIMH NIH HHS P30 MH058107NIMH NIH HHS P30MH058107NIMH NIH HHS R01 MH077553NIMH NIH HHS R01MH077553
6 · The paper itself

Abstract

objectiveWe evaluate the effect of clinic-based support by HIV-positive Peer Mentors, in addition to standard clinic care, on maternal and infant well-being among Women Living with HIV (WLH) from pregnancy through the infant's first year of life.

methodsIn a cluster randomized controlled trial in KwaZulu-Natal, South Africa, eight clinics were randomized for pregnant WLH to receive either: a Standard Care condition (SC; 4 clinics; n = 656 WLH); or an Enhanced Intervention (EI; 4 clinics; n = 544 WLH). WLH in the EI were invited to attend four antenatal and four postnatal meetings led by HIV-positive Peer Mentors, in addition to SC. WLH were recruited during pregnancy, and at least two post-birth assessment interviews were completed by 57% of WLH at 1.5, 6 or 12 months. EI's effect was ascertained on 19 measures of maternal and infant well-being using random effects regressions to control for clinic clustering. A binomial test for correlated outcomes evaluated EI's overall efficacy.

findingsWLH attended an average of 4.1 sessions (SD = 2.0); 13% did not attend any sessions. Significant overall benefits were found in EI compared to SC using the binomial test. Secondarily, over time, WLH in the EI reported significantly fewer depressive symptoms and fewer underweight infants than WLH in the SC condition. EI WLH were significantly more likely to use one feeding method for six months and exclusively breastfeed their infants for at least 6 months.

conclusionsWLH benefit by support from HIV-positive Peer Mentors, even though EI participation was partial, with incomplete follow-up rates from 6-12 months.

trial registrationClinicalTrials.gov NCT00972699.

Indexed as

MentorsAdultAnti-HIV AgentsCluster AnalysisFemaleHealth Knowledge, Attitudes, PracticeHIV InfectionsHumansInfantInfant, NewbornInfectious Disease Transmission, VerticalMaternal Health ServicesPeer GroupPostnatal CarePregnancyPregnancy Complications, InfectiousAnti-HIV Agents

Identifiers

PMID24465444
PMCPMC3898948
OpenAlexW1995923504

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.