ArticlePloS one2014
Genetic polymorphism characteristics of Brucella canis isolated in China.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 27 citations in OpenAlex.
- Evolution and phylogenetic characteristics of the firstFrontiers in cellular and infection microbiology · 2025Article
- Identification of Dendritic Cell Maturation, TLR, and TREM1 Signaling Pathways in theFrontiers in veterinary science · 2021Article
- Canine Brucellosis: An Update.Frontiers in veterinary science · 2021Review
- Prevalence and Genomic Characterization ofAnimals : an open access journal from MDPI · 2020Article
- Serological and Molecular Investigation ofPathogens (Basel, Switzerland) · 2019Article
- Canine Brucellosis: Insights Into the Epidemiologic Situation in Europe.Frontiers in veterinary science · 2019Article
- Genetic polymorphisms identify in species/biovars of Brucella isolated in China between 1953 and 2013 by MLST.BMC microbiology · 2018Article
- Multi-locus variable-number tandem repeat analysis of Chinese Brucella strains isolated from 1953 to 2013.Infectious diseases of poverty · 2017Article
- Genotyping Brucella canis isolates using a highly discriminatory multilocus variable-number tandem-repeat analysis (MLVA) assay.Scientific reports · 2017Article
- MLVA and LPS Characteristics ofFrontiers in veterinary science · 2017Article
- MLVA and MLST typing of Brucella from Qinghai, China.Infectious diseases of poverty · 2016Article
- Brucella canis is an intracellular pathogen that induces a lower proinflammatory response than smooth zoonotic counterparts.Infection and immunity · 2015Article
- Retrospective and prospective perspectives on zoonotic brucellosis.Frontiers in microbiology · 2014Review
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Authors and funding
18 authors at 7 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In China, brucellosis is an endemic disease typically caused by Brucella melitensis infection (biovars 1 and 3). Brucella canis infection in dogs has not traditionally recognized as a major problem. In recent years however, brucellosis resulting from Brucella canis infection has also been reported, suggesting that infections from this species may be increasing. Data concerning the epidemiology of brucellosis resulting from Brucella canis infection is limited. Therefore, the purpose of this study was to assess the diversity among Chinese Brucella canis strains for epidemiological purposes. First, we employed a 16-marker VNTR assay (Brucella MLVA-16) to assess the diversity and epidemiological relationship of 29 Brucella canis isolates from diverse locations throughout China with 38 isolates from other countries. MLVA-16 analysis separated the 67 Brucella canis isolates into 57 genotypes that grouped into five clusters with genetic similarity coefficients ranging from 67.73 to 100%. Moreover, this analysis revealed a new genotype (2-3-9-11-3-1-5-1:118), which was present in two isolates recovered from Guangxi in 1986 and 1987. Second, multiplex PCR and sequencing analysis were used to determine whether the 29 Chinese Brucella canis isolates had the characteristic BMEI1435 gene deletion. Only two isolates had this deletion. Third, amplification of the omp25 gene revealed that 26 isolates from China had a T545C mutation. Collectively, this study reveals that considerable diversity exists among Brucella canis isolates in China and provides resources for studying the genetic variation and microevolution of Brucella.
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