ArticlePloS one2014
Possible race and gender divergence in association of genetic variations with plasma von Willebrand factor: a study of ARIC and 1000 genome cohorts.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 24 citations in OpenAlex.
- The Autosomal Short Tandem Repeat Polymorphisms Are Potentially Associated with Cardiovascular Disease Predisposition in the Latin American Population: A Mini Review.BioMed research international · 2023Review
- Structure-Based Cyclic Glycoprotein Ibα-Derived Peptides Interfering with von Willebrand Factor-Binding, Affecting Platelet Aggregation under Shear.International journal of molecular sciences · 2022Article
- Phenotypic and Genotypic Signatures ofInternational journal of general medicine · 2022Article
- Analytical characterization and reference interval of an enzyme-linked immunosorbent assay for active von Willebrand factor.PloS one · 2019Article
- The commonBlood advances · 2018Article
- [Detection and analysis of plasma VWF levels in healthy Chinese by automatic standardized assay].Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi · 2017Article
- Article
- What have we learned from large population studies of von Willebrand disease?Hematology. American Society of Hematology. Education Program · 2016Review
- ABO blood group associations with markers of endothelial dysfunction in the Multi-Ethnic Study of Atherosclerosis.Atherosclerosis · 2016Article
- The ABO Histo-Blood Group and AKI in Critically Ill Patients with Trauma or Sepsis.Clinical journal of the American Society of Nephrology : CJASN · 2015Article
- Article
- Association of vWA and TPOX polymorphisms with venous thrombosis in Mexican mestizos.BioMed research international · 2014Article
- Coagulation Status and Venous Thromboembolism Risk in African Americans: A Potential Risk Factor in COVID-19.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/HemostasisArticle
Corrections and comments
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Authors and funding
10 authors at 8 institutions in 3 countries.
Funding
Abstract
The synthesis, secretion and clearance of von Willebrand factor (VWF) are regulated by genetic variations in coding and promoter regions of the VWF gene. We have previously identified 19 single nucleotide polymorphisms (SNPs), primarily in introns that are associated with VWF antigen levels in subjects of European descent. In this study, we conducted race by gender analyses to compare the association of VWF SNPs with VWF antigen among 10,434 healthy Americans of European (EA) or African (AA) descent from the Atherosclerosis Risk in Communities (ARIC) study. Among 75 SNPs analyzed, 13 and 10 SNPs were associated with VWF antigen levels in EA male and EA female subjects, respectively. However, only one SNP (RS1063857) was significantly associated with VWF antigen in AA females and none was in AA males. Haplotype analysis of the ARIC samples and studying racial diversities in the VWF gene from the 1000 genomes database suggest a greater degree of variations in the VWF gene in AA subjects as compared to EA subjects. Together, these data suggest potential race and gender divergence in regulating VWF expression by genetic variations.
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Registered trials
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