ArticlePLoS genetics2014
New microRNAs in Drosophila--birth, death and cycles of adaptive evolution.
Article in PLoS genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed.
- miR-10-3p, but not miR-1006-3p, regulatesmicroPublication biology · 2026Article
- Recurrent expansion and rapid evolution of the Drosophilid RNAi pathway in testis.bioRxiv : the preprint server for biology · 2025Article
- MicroRNA-mediated network redundancy is constrained by purifying selection and contributes to expression robustness in Drosophila melanogaster.Communications biology · 2024Article
- Mitochondrially mediated RNA interference, a retrograde signaling system affecting nuclear gene expression.Heredity · 2024Article
- Clustering pattern and evolution characteristic of microRNAs in grass carp (Ctenopharyngodon idella).BMC genomics · 2023Article
- Canalization of Phenotypes-When the Transcriptome is Constantly but Weakly Perturbed.Molecular biology and evolution · 2023Article
- Spatiotemporal Regulation of a Single Adaptively Evolving Trans-Regulatory Element Contributes to Spermatogenetic Expression Divergence in Drosophila.Molecular biology and evolution · 2022Article
- The Chromosomal Distribution of Sex-Biased MicroRNAs in Drosophila is Nonadaptive.Genome biology and evolution · 2022Article
- Yak miR-2285o-3p attenuates hypoxia-induced apoptosis by targeting caspase-3.Animal genetics · 2022Article
- Run or Die in the Evolution of New MicroRNAs-Testing the Red Queen Hypothesis on De Novo New Genes.Molecular biology and evolution · 2021Article
- A Rapid Evolving microRNA Cluster Rewires Its Target Regulatory Networks inFrontiers in genetics · 2021Article
- Evolutionary dynamics of microRNA target sites across vertebrate evolution.PLoS genetics · 2020Article
- Gene regulatory network stabilized by pervasive weak repressions: microRNA functions revealed by the May-Wigner theory.National science review · 2019Article
- Modulation of miRNA expression in natural populations of A. thaliana along a wide altitudinal gradient of Indian Himalayas.Scientific reports · 2019Article
- Death of new microRNA genes inGenome research · 2018Article
- Well-Annotated microRNAomes Do Not Evidence Pervasive miRNA Loss.Genome biology and evolution · 2018Article
- MicroRNA duplication accelerates the recruitment of new targets during vertebrate evolution.RNA (New York, N.Y.) · 2018Article
- On the possibility of death of new genes - evidence from the deletion of de novo microRNAs.BMC genomics · 2018Article
- Direct measurement of pervasive weak repression by microRNAs and their role at the network level.BMC genomics · 2018Article
- Origin, Evolution, and Loss of Bacterial Small RNAs.Microbiology spectrum · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The origin and evolution of new microRNAs (miRNAs) is important because they can impact the transcriptome broadly. As miRNAs can potentially emerge constantly and rapidly, their rates of birth and evolution have been extensively debated. However, most new miRNAs identified appear not to be biologically significant. After an extensive search, we identified 12 new miRNAs that emerged de novo in Drosophila melanogaster in the last 4 million years (Myrs) and have been evolving adaptively. Unexpectedly, even though they are adaptively evolving at birth, more than 94% of such new miRNAs disappear over time. They provide selective advantages, but only for a transient evolutionary period. After 30 Myrs, all surviving miRNAs make the transition from the adaptive phase of rapid evolution to the conservative phase of slow evolution, apparently becoming integrated into the transcriptional network. During this transition, the expression shifts from being tissue-specific, predominantly in testes and larval brain/gonads/imaginal discs, to a broader distribution in many other tissues. Interestingly, a measurable fraction (20-30%) of these conservatively evolving miRNAs experience "evolutionary rejuvenation" and begin to evolve rapidly again. These rejuvenated miRNAs then start another cycle of adaptive - conservative evolution. In conclusion, the selective advantages driving evolution of miRNAs are themselves evolving, and sometimes changing direction, which highlights the regulatory roles of miRNAs.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.