ArticlePLoS biology2014
Limiting damage during infection: lessons from infection tolerance for novel therapeutics.
Article in PLoS biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
47 citing papers in PubMed, 122 citations in OpenAlex.
- Prolonged exposure to heat enhances mosquito tolerance to viral infection.Communications biology · 2025Article
- Roles of Oxidative Stress and Nrf2 Signaling in Pathogenic and Non-Pathogenic Cells: A Possible General Mechanism of Resistance to Therapy.Antioxidants (Basel, Switzerland) · 2023Review
- Intraspecific genetic variation in host vigour, viral load and disease tolerance during Drosophila C virus infection.Open biology · 2023Article
- Discovery and Characterization of Synthesized and FDA-Approved Inhibitors of Clostridial and Bacillary Collagenases.Journal of medicinal chemistry · 2022Article
- Mechanisms of damage prevention, signalling and repair impact disease tolerance.Proceedings. Biological sciences · 2022Article
- The predicted impact of resource provisioning on the epidemiological responses of different parasites.The Journal of animal ecology · 2022Article
- Autophagy induced by taurolidine protects against polymicrobial sepsis by promoting both host resistance and disease tolerance.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Balancing sensitivity, risk, and immunopathology in immune regulation.Current opinion in insect science · 2022Review
- Disease tolerance alters host competence in a wild songbird.Biology letters · 2021Article
- Adaptive Therapy for Metastatic Melanoma: Predictions from Patient Calibrated Mathematical Models.Cancers · 2021Article
- Evolution of human respiratory virus epidemics.F1000Research · 2021Article
- Host Susceptibility ModulatesFrontiers in microbiology · 2021Article
- Evolution of Human Respiratory Virus Epidemics.medRxiv : the preprint server for health sciences · 2020Article
- Making sense of Integrated Pest Management (IPM) in the light of evolution.Evolutionary applications · 2020Article
- Combining antibiotics with antivirulence compounds can have synergistic effects and reverse selection for antibiotic resistance in Pseudomonas aeruginosa.PLoS biology · 2020Article
- NHR-49 Transcription Factor Regulates Immunometabolic Response and Survival of Caenorhabditis elegans during Enterococcus faecalis Infection.Infection and immunity · 2020Article
- Proliferation and benevolence-A framework for dissecting the mechanisms of microbial virulence and health promotion.Evolutionary applications · 2020Article
- Steering Phages to Combat Bacterial Pathogens.Trends in microbiology · 2020Review
- Sequential infection can decrease virulence in a fish-bacterium-fluke interaction: Implications for aquaculture disease management.Evolutionary applications · 2019Article
- Mathematical model predicts anti-adhesion-antibiotic-debridement combination therapies can clear an antibiotic resistant infection.PLoS computational biology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The distinction between pathogen elimination and damage limitation during infection is beginning to change perspectives on infectious disease control, and has recently led to the development of novel therapies that focus on reducing the illness caused by pathogens (‘‘damage limitation’’)rather than reducing pathogen burdens directly (‘‘pathogen elimination’’). While beneficial at the individual host level, the population consequences of these interventions remain unclear. To address this issue,we present a simple conceptual framework for damage limitation during infection that distinguishes between therapies that are either host-centric (pro-tolerance) or pathogen-centric (anti-virulence). We then draw on recent developments from the evolutionary ecology of disease tolerance to highlight some potential epidemiological and evolutionary responses of pathogens to medical interventions that target the symptoms of infection. Just as pathogens are known to evolve in response to antimicrobial and vaccination therapies, we caution that claims of ‘‘evolution-proof’’ anti-virulence interventions may be premature, and further, that in infections where virulence and transmission are linked, reducing illness without reducing pathogen burden could have non-trivial epidemiological and evolutionary consequences that require careful examination.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.