ArticleSynthesis2012
Synthetic Routes to a Series of Proximal and Distal 2'-Deoxy Fleximers.
Article in Synthesis, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed.
- Novel tricycle expanded purine nucleosides with pan-viral activity.Bioorganic & medicinal chemistry · 2025Article
- Synthesis and biological evaluation of novel flexible nucleoside analogues that inhibit flavivirus replication in vitro.Bioorganic & medicinal chemistry · 2020Article
- An Expedient Synthesis of Flexible Nucleosides through Enzymatic Glycosylation of Proximal and Distal Fleximer Bases.Chembiochem : a European journal of chemical biology · 2020Article
- Nucleoside Analogs with Fleximer Nucleobase.Chemistry of heterocyclic compounds · 2020Article
- Probing the Effects of Pyrimidine Functional Group Switches on Acyclic Fleximer Analogues for Antiviral Activity.Molecules (Basel, Switzerland) · 2019Article
- Synthesis of distal and proximal fleximer base analogues and evaluation in the nucleocapsid protein of HIV-1.Bioorganic & medicinal chemistry · 2019Article
- The evolution of antiviral nucleoside analogues: A review for chemists and non-chemists. Part II: Complex modifications to the nucleoside scaffold.Antiviral research · 2019Review
- Flex-nucleoside analogues - Novel therapeutics against filoviruses.Bioorganic & medicinal chemistry letters · 2017Article
- Thiophene-expanded guanosine analogues of Gemcitabine.Bioorganic & medicinal chemistry letters · 2015Article
- Design, synthesis and evaluation of a series of acyclic fleximer nucleoside analogues with anti-coronavirus activity.Bioorganic & medicinal chemistry letters · 2015Article
- Design and synthesis of a series of truncated neplanocin fleximers.Molecules (Basel, Switzerland) · 2014Article
- "Reverse" carbocyclic fleximers: synthesis of a new class of adenosine deaminase inhibitors.Nucleosides, nucleotides & nucleic acids · 2013Article
- Flexibility-Not just for yoga anymore!Antiviral chemistry & chemotherapyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Two series of innovative 2'-deoxy nucleoside analogues have been designed where the nucleobase has been split into its imidazole and pyrimidine subunits. This structural modification serves to introduce flexibility into the nucleobase scaffold while still retaining the elements required for recognition. The synthetic efforts to realize these analogues are described within.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.