ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2014
Longitudinal assessment of the menopausal transition, endogenous sex hormones, and perception of physical functioning: the Study of Women's Health Across the Nation.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Citalopram Improves Vasomotor and Urogenital Syndromes in Mexican Patients With Post-menopause
Efficacy of Nano-Pso Therapy Compared to Placebo in the Control of Vasomotor Symptomatology in Early Menopause
Who cites it
19 citing papers in PubMed, 47 citations in OpenAlex.
- Geriatric syndromes in women living with HIV.Current opinion in HIV and AIDS · 2026Review
- Low physical function following cancer diagnosis is associated with higher mortality risk in postmenopausal women.Journal of the National Cancer Institute · 2024Article
- Estimation of Sarcopenia Indices in Women from Saudi Arabia in Relation to Menopause and Obesity: Cross-Sectional Comparative Study.Journal of clinical medicine · 2023Article
- Menopausal symptoms by HIV status and association with health-related quality of life among women in Zimbabwe: a cross-sectional study.BMC women's health · 2023Article
- Aging and changes in adiposity indices: the impact of menopause.Journal of endocrinological investigation · 2022Article
- Physical activity recommendation by health care providers to adults with and without functional limitations.Preventive medicine · 2021Article
- The role of cardiorespiratory fitness on quality of life in midlife women.Menopause (New York, N.Y.) · 2021Article
- Prevalence of Hysterectomy by Self-Reported Disability Among Canadian Women: Findings from a National Cross-Sectional Survey.Women's health reports (New Rochelle, N.Y.) · 2021Article
- Identifying women who share patterns of reproductive hormones, vasomotor symptoms, and sleep maintenance problems across the menopause transition: group-based multi-trajectory modeling in the Study of Women's Health Across the Nation.Menopause (New York, N.Y.) · 2020Article
- The menopause transition and women's health at midlife: a progress report from the Study of Women's Health Across the Nation (SWAN).Menopause (New York, N.Y.) · 2019 · on this mapReview
- Age at natural menopause and physical functioning in postmenopausal women: the Canadian Longitudinal Study on Aging.Menopause (New York, N.Y.) · 2019Article
- Factors Influencing Longitudinal Stair Climb Performance from Midlife to Early Late Life: The Study of Women's Health Across the Nation Chicago and Michigan Sites.The journal of nutrition, health & aging · 2019Article
- Physical Activity and Physical Function: Moving and Aging.Obstetrics and gynecology clinics of North America · 2018Review
- Design and protocol of Estrogenic Regulation of Muscle Apoptosis (ERMA) study with 47 to 55-year-old women's cohort: novel results show menopause-related differences in blood count.Menopause (New York, N.Y.) · 2018Article
- Hysterectomy and perceived physical function in middle-aged Australian women: a 20-year population-based prospective cohort study.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2018Article
- Article
- Recommendations for the conduct of clinical trials for drugs to treat or prevent sarcopenia.Aging clinical and experimental research · 2016Review
- Menopausal status and physical performance in middle aged women: a cross-sectional community-based study in Northeast Brazil.PloS one · 2015Article
- Sex hormone exposure and reproductive factors in pulmonary arterial hypertension: a case-control study.Pulmonary circulationArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundTo evaluate the longitudinal associations between menopausal status, related hormonal changes, and level of self-reported physical functioning.
methodsStudy included 2,495 women (age: 45-57 between 2000 and 2001) from the Study of Women's Health Across the Nation. Physical functioning scale of the Medical Outcomes Study Short-Form (SF-36; score 0-100) was categorized as: no limitation (86-100), moderate limitation (51-85), and substantial limitation (0-50). Study variables were collected between 2000 (visit-04) and 2011 (visit-12) at five timepoints. Statistical models were adjusted for age at visit-04, time since visit-04, ethnicity, site, economic status, level and change in body mass index, level and change in physical activity, and presence of comorbid conditions.
resultsIn final models, natural and surgical postmenopausal women had significantly higher odds of functional limitation, compared with premenopausal women. Less reduction in estradiol and testosterone since visit-04 were significantly associated with lower odds of functional limitation, while greater increase in sex hormone-binding globulin was associated with higher odds of functional limitation.
conclusionsOur findings suggest the menopause-related changes in endogenous sex hormones as a possible mechanism of action to explain the greater limitation in physical functioning reported in women at midlife.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.