SynthesisThe Cochrane database of systematic reviews2014
Antiepileptic drugs for the primary and secondary prevention of seizures after stroke.
Synthesis in The Cochrane database of systematic reviews, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 96 citations in OpenAlex.
- Antiepileptic drugs for the primary and secondary prevention of seizures after stroke.The Cochrane database of systematic reviews · 2022Pooled it
- Association between seizures after ischemic stroke and stroke outcome: A systematic review and meta-analysis.Medicine · 2016Pooled it
- Antiepileptogenesis after stroke-trials and tribulations: Methodological challenges and recruitment results of a Phase II study with eslicarbazepine acetate.Epilepsia open · 2023Trial
- Anti-seizure medications in patients with post-stroke epilepsy: A survival analysis study.Epilepsia · 2026Article
- Long-Term Safety and Efficacy of Lacosamide Combined with NOACs in Post-Stroke Epilepsy and Atrial Fibrillation: A Prospective Longitudinal Study.Journal of personalized medicine · 2024Article
- Role of the glymphatic system and perivascular spaces as a potential biomarker for post-stroke epilepsy.Epilepsia open · 2024Review
- Cortical Involvement of a Recent Infarct Contralateral to Early Focal Seizures in Ischemic Stroke.Internal medicine (Tokyo, Japan) · 2023Article
- Incidence and risk factors of epilepsy following brain arteriovenous malformation rupture in adult patients.Journal of neurology · 2022Article
- Frequency and factors associated with post-stroke seizures in a large multicenter study in West Africa.Journal of the neurological sciences · 2021Article
- Repurposed molecules for antiepileptogenesis: Missing an opportunity to prevent epilepsy?Epilepsia · 2020Review
- The antiepileptic effect of Gastrodiae Rhizoma through modulating overexpression of mTOR and attenuating astrogliosis in pilocarpine mice model.Epilepsia open · 2020Article
- Poststroke seizure: optimising its management.Stroke and vascular neurology · 2019Review
- Role of cerebral glutamate in post-stroke epileptogenesis.NeuroImage. Clinical · 2019Review
- The occurrence of seizures after ischemic stroke does not influence long-term mortality; a 26-year follow-up study.Journal of neurology · 2018Article
- Neuro-Coagulopathy: Blood Coagulation Factors in Central Nervous System Diseases.International journal of molecular sciences · 2017Review
- European Stroke Organisation guidelines for the management of post-stroke seizures and epilepsy.European stroke journal · 2017Article
- Clinical predictors of seizure recurrence after the first post-ischemic stroke seizure.BMC neurology · 2016Article
- Poststroke epilepsy: update and future directions.Therapeutic advances in neurological disorders · 2016Review
- Seizures Following Ischemic Stroke: Frequency of Occurrence and Impact on Outcome in a Long-Term Population-Based Study.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2016Article
- Modeling early-onset post-ischemic seizures in aging mice.Experimental neurology · 2015Article
Corrections and comments
- Updated by
- Update of
Authors and funding
3 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis is an updated version of the original Cochrane review published in 2010, Issue 1. Seizures after stroke are an important clinical problem, and they may be associated with poor outcome. The effects of antiepileptic drugs for the primary and secondary prevention of seizures after stroke remain unclear.
objectivesWe aimed to assess the effects of antiepileptic drugs for the primary and secondary prevention of seizures after stroke. SEARCH
methodsWe searched the Specialised Registers of the Cochrane Epilepsy Group (12 August 2013) and the Cochrane Stroke Group (12 August 2013), the Cochrane Central Register of Controlled Trials (CENTRAL, The Cochrane Library 2013, Issue 7), and MEDLINE (OVID, 1946 to 12 August 2013). We also checked the reference lists of articles retrieved from these searches. SELECTION CRITERIA: Randomised and quasi-randomised controlled trials in which participants were assigned to treatment or control group (placebo or no drug). DATA COLLECTION AND ANALYSIS: Two review authors independently screened all the titles, abstracts, and keywords of publications identified by the searches to assess their eligibility, and both review authors assessed their suitability for inclusion according to prespecified selection criteria. We included only one study for data collection and analysis. MAIN
resultsWe found only one trial that fulfilled the study inclusion criteria of comparison of the effects of an antiepileptic drug with placebo (or no drug) for the primary or secondary prevention of seizures after stroke. This was a prospective randomised, double-blind, placebo-controlled trial comparing valproic acid with placebo for primary prevention of seizures in 72 adults (over 18 years of age) with spontaneous non-aneurysmal, non-traumatic intracerebral haemorrhage; no statistically significant difference in outcome (seizure occurrence at one year) was demonstrated between groups. AUTHORS'
conclusionsCurrently, there is insufficient evidence to support the routine use of antiepileptic drugs for the primary or secondary prevention of seizures after stroke. Further well-conducted research is needed for this important clinical problem.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.