ArticleThe journal of physiological sciences : JPS2014
Anxiolytic-like effects of mitragynine in the open-field and elevated plus-maze tests in rats.
Article in The journal of physiological sciences : JPS, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.
- A systematic review of (pre)clinical studies on the therapeutic potential and safety profile of kratom in humans.Human psychopharmacology · 2022Pooled it
- Investigating Opioid Receptor Activity through Biocatalytic Halogenation and Oxidation of Mitragynine.ACS chemical biology · 2026Article
- Observational real-world analysis of dose-dependent effects ofFrontiers in pharmacology · 2026Article
- Oral administration of kratom leaf extract alleviates anxiety-like behavior, urinary bladder pain, voiding dysfunction, and bladder hypercontractility via attenuating muscarinic receptor response in male mice exposed to chronic water avoidance stress.Frontiers in neuroscience · 2026Article
- Dapagliflozin Ameliorates Doxorubicin-Induced Chemobrain and Cognitive Abnormalities in Rats: Modulation of AKT/GSK-3β and Wnt/β-Catenin Pathways.Neurochemical research · 2025Article
- Ameliorative Effect of Moringa oleifera Against CUMS-Induced Anxiety in Rats: β-Catenin and 5-HTMolecular neurobiology · 2025Article
- Acute Anxiolytic Effects of Salvia Heldreichiana Essential Oil in Rats: Reduction in Serum Cortisol.Brain and behavior · 2025Article
- Plant hormone jasmonic acid reduces anxiety behavior in mice.Scientific reports · 2025Article
- Effects of repeated social stress on risk assessment behaviors and response to diazepam in the elevated plus maze in adult male rats.Behavioral neuroscience · 2025Article
- Anti-Stress Effects ofNutrients · 2025Article
- Endogenous Opioid Activity as the Mechanism of Action for Mitragyna speciosa (Kratom): The Current State of the Evidence.Advances in neurobiology · 2024Review
- Searching for a Signal: Self-Reported Kratom Dose-Effect Relationships Among a Sample of US Adults With Regular Kratom Use Histories.Frontiers in pharmacology · 2022Article
- Variations in mitragynine content in the naturally growing Kratom (Frontiers in plant science · 2022Article
- Adolescent kratom exposure affects cognitive behaviours and brain metabolite profiles in Sprague-Dawley rats.Frontiers in pharmacology · 2022Article
- Pentylenetetrazol-like stimulus is not produced following naloxone-precipitated mitragynine withdrawal in rats.Psychopharmacology · 2021Article
- Kratom pharmacology: Clues from planarians exposed to mitragynine.Physiology & behavior · 2021Article
- Kratom Alkaloids: Interactions With Enzymes, Receptors, and Cellular Barriers.Frontiers in pharmacology · 2021Review
- Mitragynine (Kratom)-Induced Cognitive Impairments in Mice Resemble Δ9-THC and Morphine Effects: Reversal by Cannabinoid CBFrontiers in pharmacology · 2021Article
- Antioxidant Activity, Molecular Docking, Quantum Studies andFrontiers in pharmacology · 2021Article
- Pharmacokinetics and Safety of Mitragynine in Beagle Dogs.Planta medica · 2020Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The effects of mitragynine on anxiety-related behaviours in the open-field and elevated plus-maze tests were evaluated. Male Sprague-Dawley rats were orally treated with mitragynine (10, 20 and 40 mg/kg) or diazepam (10 mg/kg) 60 min before behavioural testing. Mitragynine doses used in this study were selected on the basis of approximately human equivalent doses with reference to our previous literature reports. Acute administration of mitragynine (10, 20 and 40 mg/kg) or diazepam (10 mg/kg) increased central zone and open arms exploration in the open-field and elevated plus-maze tests respectively. These anxiolytic-like effects of mitragynine were effectively antagonized by intraperitoneal administration of naloxone (2 mg/kg), flumazenil (10 mg/kg), sulpiride (0.5 mg/kg) or SCH 23390 (0.02 mg/kg) 15 min before mitragynine treatments. These findings reveal that the acute administration of mitragynine produces anxiolytic-like effects and this could be possibly attributed to the interactions among opioidergic, GABAergic and dopaminergic systems in brain regions involved in anxiety.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.