ArticleInflammation2014
Aging reduces the expression of lung CINC and MCP-1 mRNA in a P. aeruginosa rat model of infection.
Article in Inflammation, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 11 citations in OpenAlex.
- Impact of positive biphasic pressure during low and high inspiratory efforts in Pseudomonas aeruginosa-induced pneumonia.PloS one · 2021Article
- Increased mortality in elderly patients with acute respiratory distress syndrome is not explained by host response.Intensive care medicine experimental · 2019Article
- Using ROS as a Second Messenger, NADPH Oxidase 2 Mediates Macrophage Senescence via Interaction with NF-Oxidative medicine and cellular longevity · 2018Article
- Aging increases the expression of lung CINCs and MCP-1 in senile patients with pneumonia.Oncotarget · 2017Article
- Age Impacts Pulmonary Inflammation and Systemic Bone Response to Inhaled Organic Dust Exposure.Journal of toxicology and environmental health. Part A · 2015Article
- Immunosenescence in monocytes, macrophages, and dendritic cells: lessons learned from the lung and heart.Immunology letters · 2014Review
- Inhaled lactonase reduces Pseudomonas aeruginosa quorum sensing and mortality in rat pneumonia.PloS one · 2014Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We investigated dynamic changes of inflammatory cell infiltration and expression of cytokine-induced neutrophil chemoattractant (CINC) and monocyte chemoattractant protein-1 (MCP-1) mRNA in aged rats with Pseudomonas aeruginosa pulmonary infection. Disease manifestation and lung tissue pathology (lesion dispersion, inflammatory reactions, tissue edema and bleeding) were more severe in aged rats than young rats. At various time points, lung tissue polymorphonuclear neutrophil and mononuclear macrophage numbers were lower in the aged group than the young group (P < 0.05), and at 24 h there was no difference in mononuclear macrophage numbers. After inoculation with P. aeruginosa, CINC and MCP-1 mRNA expression increased in both groups, but the peak lagged in old rats compared with young. Thus, aging can reduce the expression of CINC and MCP-1 mRNA in lung tissues, and reduce the infiltration of neutrophils and monocyte-macrophages induced by CINC and MCP-1. This might lead to increased risk of pneumonia in elderly patients.
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Registered trials
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