ArticleHuman brain mapping2014
Cerebellar networks in individuals at ultra high-risk of psychosis: impact on postural sway and symptom severity.
Article in Human brain mapping, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
72 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- A Meta-Analysis of Neural Correlates of Reward Anticipation in Individuals at Clinical Risk for Schizophrenia.The international journal of neuropsychopharmacology · 2023Pooled it
- Cerebellar volume and cerebellocerebral structural covariance in schizophrenia: a multisite mega-analysis of 983 patients and 1349 healthy controls.Molecular psychiatry · 2018Pooled it
- Patients with schizophrenia show aberrant patterns of basal ganglia activation: Evidence from ALE meta-analysis.NeuroImage. Clinical · 2017Pooled it
- Postural Sway and Clinical Characteristics in Patients with Psychotic Disorders: A Review.The Psychiatric quarterly · 2015Pooled it
- Cerebellar Transcranial Direct Current Stimulation Improves Procedural Learning in Nonclinical Psychosis: A Double-Blind Crossover Study.Schizophrenia bulletin · 2018Trial
- Schizophrenia and disordered sensorimotor control: challenges, mechanisms and opportunities.Brain : a journal of neurology · 2026Review
- Positive and negative falls short: why any attempt to rename schizophrenia must include careful consideration of the sensori-/psychomotor domain.European archives of psychiatry and clinical neuroscience · 2026Article
- Spontaneous head movements during virtual clinical interviews help predict 12-months clinical outcomes in youth at clinical high risk for psychosis.Schizophrenia (Heidelberg, Germany) · 2025Article
- Capturing Motor Signs in Psychosis: How the New Technologies Can Improve Assessment and Treatment?Schizophrenia bulletin · 2025Article
- The Association Between Childhood Impaired Motor Development and Adolescent Psychotic Experiences.Developmental psychobiology · 2025Article
- Connectome-based predictive modeling of early and chronic psychosis symptoms.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Relationships of functional connectivity of motor cortex, primary somatosensory cortex, and cerebellum to balance performance in middle-aged and older adults.Neurobiology of aging · 2025Article
- Psychomotor slowing in schizophrenia is associated with aberrant postural control.Schizophrenia (Heidelberg, Germany) · 2024Article
- Motor actions across psychiatric disorders: A research domain criteria (RDoC) perspective.Clinical psychology review · 2024Review
- Motor precision deficits in clinical high risk for psychosis.European archives of psychiatry and clinical neuroscience · 2024Article
- Resting-State Functional Connectivity Explained Psychotic-like Experiences in the General Population and Partially Generalized to Patients and Relatives.Biological psychiatry global open science · 2023Article
- Speech characteristics yield important clues about motor function: Speech variability in individuals at clinical high-risk for psychosis.Schizophrenia (Heidelberg, Germany) · 2023Article
- Gesticulation in individuals with at risk mental states for psychosis.Schizophrenia (Heidelberg, Germany) · 2023Article
- Cerebellar Functional Dysconnectivity in Drug-Naïve Patients With First-Episode Schizophrenia.Schizophrenia bulletin · 2023Article
- Motion energy analysis during speech tasks in medication-naïve individuals with at-risk mental states for psychosis.Schizophrenia (Heidelberg, Germany) · 2022Article
12 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Despite known deficits in postural control in patients with schizophrenia, this domain has not been investigated in youth at ultra high-risk (UHR) for psychosis. This is particularly relevant as postural control implicates dysfunction in the cerebellum-a region implicated in cognitive dysmetria conceptions of schizophrenia but poorly understood in the prodrome. Here, we extended our understanding of movement abnormalities in UHR individuals to include postural control, and have linked these deficits to both symptom severity and cerebello-cortical network connectivity. UHR and healthy control participants completed an instrumentally based balance task to quantify postural control along with a resting state brain imaging scan to investigate cerebellar networks. We also quantified positive and negative symptom severity with structured clinical interviews. The UHR group showed overall increased postural sway and decreased cerebello-cortical resting state connectivity, relative to controls. The decreased cerebello-cortical connectivity was seen across multiple networks. Postural sway was also correlated with cerebellar connectivity in this population and uniquely positively correlated with the severity of negative symptoms. Finally, symptom severity was also associated with cerebellar connectivity. Together, our results point to a potential deficit in sensory integration as an underlying contributor to the increased postural sway, and provide evidence of cerebellar abnormalities in UHR individuals. These results extend our understanding of the motor abnormalities of UHR individuals beyond striatum-based dyskinesias to include postural control and sensory integration deficits, and implicate the cerebellum as a distinct neural substrate preceding the onset of psychosis. Taken together, our results extend the cognitive dysmetria framework to UHR populations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.