ArticleThe Plant cell2014
Arabidopsis KANADI1 acts as a transcriptional repressor by interacting with a specific cis-element and regulates auxin biosynthesis, transport, and signaling in opposition to HD-ZIPIII factors.
Article in The Plant cell, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers, 1 of them a synthesis that pooled it.
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78 citing papers in PubMed, 1 synthesis or guideline pooled it, 117 citations in OpenAlex.
- Meta-Analysis of Arabidopsis KANADI1 Direct Target Genes Identifies a Basic Growth-Promoting Module Acting Upstream of Hormonal Signaling Pathways.Plant physiology · 2015Pooled it
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- Beyond dormancy: organ-specific gene regulatory networks control winter development in peach buds.Horticulture research · 2026Article
- Characterization of a KANADI-like transcription factor that suppresses pear anthocyanin biosynthesis.Horticulture research · 2025Article
- Genome-wide association study (GWAS) analyses of early anatomical changes in rose adventitious root formation.Scientific reports · 2024Article
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- The Ins and Outs of Homeodomain-Leucine Zipper/Hormone Networks in the Regulation of Plant Development.International journal of molecular sciences · 2024Review
- Genome-wide characterisation of HD-Zip transcription factors and functional analysis of PbHB24 during stone cell formation in Chinese white pear (Pyrus bretschneideri).BMC plant biology · 2024Article
- Identification of the domestication gene GmCYP82C4 underlying the major quantitative trait locus for the seed weight in soybean.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2024Article
- A graph-based pan-genome of Brassica oleracea provides new insights into its domestication and morphotype diversification.Plant communications · 2024Article
- Differential CaKAN3-CaHSF8 associations underlie distinct immune and heat responses under high temperature and high humidity conditions.Nature communications · 2023Article
- Precise Regulation of the TAA1/TAR-YUCCA Auxin Biosynthesis Pathway in Plants.International journal of molecular sciences · 2023Review
- Unique and overlapping functions for the transcriptional regulatorsPlant direct · 2023Article
- Fine Mapping of a Pleiotropic Locus (International journal of molecular sciences · 2023Article
- Size regulation of the lateral organ initiation zone and its role in determining cotyledon number in conifers.Frontiers in plant science · 2023Article
- A SNP variation in the Sucrose synthase (PeerJ · 2023Article
- Genome-Scale Investigation ofInternational journal of molecular sciences · 2022Article
- The HD-Zip transcription factor SlHB15A regulates abscission by modulating jasmonoyl-isoleucine biosynthesis.Plant physiology · 2022Article
- Article
18 more citing papers are in PubMed but not listed here.
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9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The formation of leaves and other lateral organs in plants depends on the proper specification of adaxial-abaxial (upper-lower) polarity. KANADI1 (KAN1), a member of the GARP family of transcription factors, is a key regulator of abaxial identity, leaf growth, and meristem formation in Arabidopsis thaliana. Here, we demonstrate that the Myb-like domain in KAN1 binds the 6-bp motif GNATA(A/T) and that this motif alone is sufficient to squelch transcription of a linked reporter in vivo. In addition, we report that KAN1 acts as a transcriptional repressor. Among its targets are genes involved in auxin biosynthesis, auxin transport, and auxin response. Furthermore, we find that the adaxializing HD-ZIPIII transcription factor REVOLUTA has opposing effects on multiple components of the auxin pathway. We hypothesize that HD-ZIPIII and KANADI transcription factors pattern auxin accumulation and responsiveness in the embryo. Specifically, we propose the opposing actions of KANADI and HD-ZIPIII factors on cotyledon formation (KANADI represses and HD-ZIPIII promotes cotyledon formation) occur through their opposing actions on genes acting at multiple steps in the auxin pathway.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.