SynthesisTumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine2014
Lack of association between IL-4 -588C>T polymorphism and NHL susceptibility.
Synthesis in Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Association between four SNPs in IL-4 and the risk of gastric cancer in a Chinese population.International journal of molecular epidemiology and genetics · 2017Article
- Roles of IL-4 genetic polymorphisms and haplotypes in the risk of gastric cancer and their interaction with environmental factors.International journal of clinical and experimental pathology · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The relationship of non-Hodgkin's lymphoma (NHL) with the presence of interleukin-4 genetic polymorphism -588C>T has been reported with inconsistent results. The objective of this study was to quantitatively evaluate the association between -588C>T polymorphism and NHL susceptibility. Two investigators independently searched Medline and the Cochrane Library up to September 20, 2013. Pooled odds ratio and 95% confidence interval were calculated using a fixed or random effects model. Statistical analysis was performed with Review Manage 5.0 and Stata 11. Of the six case-control studies selected for this meta-analysis, a total of 1,909 NHL cases and 1,834 controls were included. The combined results based on all studies suggested that -588C>T was not associated with NHL risk under all genetic models. When stratifying for race, no noteworthy associations were observed in mixed populations or Caucasians. This meta-analysis suggests that IL-4 -588C>T polymorphism might not be a risk factor for NHL risk. However, further well-designed studies are required to confirm our findings.
Indexed as
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.