ArticleClinical oral investigations2014
Apical periodontitis and periodontal disease increase serum IL-17 levels in normoglycemic and diabetic rats.
Article in Clinical oral investigations, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 62 citations in OpenAlex.
- Diabetes mellitus influences Toll-like receptors 2 and 4 in experimental apical periodontitis of Wistar rats.Odontology · 2026Article
- Rheumatoid arthritis exacerbates apical periodontitis in Wistar rats, increasing IL-17, TNF-α, TRAP, and RANKL levels.Odontology · 2026Article
- Cellular and molecular immunomodulatory potential of red wine polyphenols in apical periodontitis.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas · 2026Article
- Infectious/Inflammatory Oral Diseases and Medication-Related Osteonecrosis of the Jaw (MRONJ).Advances in experimental medicine and biology · 2026Review
- Endodontic Inflammatory Disease: Systemic Consequences.Advances in experimental medicine and biology · 2026Review
- Apical periodontitis and its association with systemic biomarkers: bibliometric analysis of global scientific production and knowledge compilation map.Odontology · 2026Review
- Connection between oral health and chronic diseases.MedComm · 2025Review
- Blood count, endocrine, immunologic, renal, and hepatic markers in a case-control animal study of induced periodontitis in female rodents.Frontiers in physiology · 2024Article
- Effect of Lipopolysaccharide-Induced Apical Periodontitis in Diabetes Mellitus Rats on Periapical Inflammation.European journal of dentistry · 2023Article
- Interaction between apical periodontitis and systemic disease (Review).International journal of molecular medicine · 2023Review
- The burden of diabetes on the soft tissue seal surrounding the dental implants.Frontiers in physiology · 2023Review
- Proinflammatory Cytokine Expression in Apical Periodontitis from Diabetic Patients.International journal of dentistry · 2023Article
- Protective Actions in Apical Periodontitis: The Regenerative Bioactivities Led by Mesenchymal Stem Cells.Biomolecules · 2022Review
- Accuracy of radiographic pixel linear analysis in detecting bone loss in periodontal disease: Study in diabetic rats.The Saudi dental journal · 2021Article
- Evolution of endodontic medicine: a critical narrative review of the interrelationship between endodontics and systemic pathological conditions.Odontology · 2021Review
- Inflammatory Response Mechanisms of the Dentine-Pulp Complex and the Periapical Tissues.International journal of molecular sciences · 2021Review
- Apical Periodontitis and Diabetes Mellitus Type 2: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2020Article
- C1 Silencing Attenuates Inflammation and Alveolar Bone Resorption in Endodontic Disease.Journal of endodontics · 2019Article
- Endodontic infections increase leukocyte and lymphocyte levels in the blood.Clinical oral investigations · 2018Article
- Factors affecting the periapical healing process of endodontically treated teeth.Journal of applied oral science : revista FOBReview
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThis study aimed to evaluate the influence of apical periodontitis (AP) and/or periodontal disease (PD) on serum interleukin-17 (IL-17) levels in a rat model of diabetes mellitus (DM).
methodsEighty male Wistar rats were divided into eight groups of ten animals each: normoglycemic, AP, PD, AP+PD, DM, DM+AP, DM+PD, and DM+AP+PD. DM was induced using streptozotocin, AP by dental pulp exposure to the oral environment, and PD by periodontal ligature. The animals were sacrificed after 30 days, and venous blood samples were collected via cardiac puncture to determine the serum IL-17 and neutrophil levels. The maxillae were dissected and processed for radiographic analysis. The periapical lesion areas were quantified in pixels. The total assessed values were tabulated according to each experimental group and were statistically analyzed using Spearman's correlation and Kruskal-Wallis test (p < 0.05).
resultsA significant difference in the serum IL-17 levels was observed between the groups without oral infections and the groups with AP+PD-associated lesions, regardless of the presence of DM (p < 0.05). Diabetes increased the neutrophil levels, regardless of the presence of oral infection. However, a combination of two oral infections increased the neutrophil levels in DM rats (p < 0.05). The level of bone resorption lesions was greater in DM rats than in normoglycemic rats (p < 0.05).
conclusionThe combination of AP and PD increased the serum IL-17 levels in DM and normoglycemic rats and increased the neutrophil levels in DM rats. Diabetes increased the neutrophil levels and bone resorption in rats. CLINICAL SIGNIFICANCE: AP is capable of potentiating systemic inflammatory changes when associated with PD, and increases in blood glucose can accelerate the pathogenesis of oral infections.
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