ArticleScientific reports2014
Therapeutic implication of L-phenylalanine aggregation mechanism and its modulation by D-phenylalanine in phenylketonuria.
Article in Scientific reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 130 citations in OpenAlex.
- Unveiling the phenylalanine coaggregation mechanism for a deep understanding of phenylketonuria disease.Scientific reports · 2025Article
- Spectroscopic Investigation of Hydrogels Formed from Phenylalanine.Journal of fluorescence · 2025Article
- Targeted Analysis of Serum and Urinary Metabolites for Early Chronic Kidney Disease.International journal of molecular sciences · 2025Article
- Amino Acid-Derived Supramolecular Assembly and Soft Materials.Molecules (Basel, Switzerland) · 2024Review
- A Review on the Rheological Properties of Single Amino Acids and Short Dipeptide Gels.Gels (Basel, Switzerland) · 2024Review
- T Cell-Association of Carboxy-Terminal Dendrimers with Different Bound Numbers of Phenylalanine and Their Application to Drug Delivery.Pharmaceutics · 2023Article
- Hydrogels with intrinsic antibacterial activity prepared from naphthyl anthranilamide (NaA) capped peptide mimics.Scientific reports · 2022Article
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- Polarization-sensitive optoionic membranes from chiral plasmonic nanoparticles.Nature nanotechnology · 2022Article
- Metabolite medicine offers a path beyond lists of metabolites.Communications chemistry · 2021Article
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- Tunable Chiral Optics in All-Solid-Phase Reconfigurable Dielectric Nanostructures.Nano letters · 2021Article
- Self-assembly of amino acids toward functional biomaterials.Beilstein journal of nanotechnology · 2021Review
- Nickel(II) complexes based on L-amino-acid-derived ligands: synthesis, characterization and study of the role of the supramolecular structure in carbon dioxide capture.Acta crystallographica Section B, Structural science, crystal engineering and materials · 2020Article
- Self-Assembly of Aromatic Amino Acid Enantiomers into Supramolecular Materials of High Rigidity.ACS nano · 2020Article
- Anthranilamide-based Short Peptides Self-Assembled Hydrogels as Antibacterial Agents.Scientific reports · 2020Article
- Overview on Multienzymatic Cascades for the Production of Non-canonical α-Amino Acids.Frontiers in bioengineering and biotechnology · 2020Review
- Ultrashort Peptide Self-Assembly: Front-Runners to Transport Drug and Gene Cargos.Frontiers in bioengineering and biotechnology · 2020Review
- Self-assembly of l-phenylalanine amino acid: electrostatic induced hindrance of fibril formation.RSC advances · 2019Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Self-assembly of phenylalanine is linked to amyloid formation toxicity in phenylketonuria disease. We are demonstrating that L-phenylalanine self-assembles to amyloid fibrils at varying experimental conditions and transforms to a gel state at saturated concentration. Biophysical methods including nuclear magnetic resonance, resistance by alpha-phenylglycine to fibril formation and preference of protected phenylalanine to self-assemble show that this behaviour of L-phenylalanine is governed mainly by hydrophobic interactions. Interestingly, D-phenylalanine arrests the fibre formation by L-phenylalanine and gives rise to flakes. These flakes do not propagate further and prevent fibre formation by L-phenylalanine. This suggests the use of D-phenylalanine as modulator of L-phenylalanine amyloid formation and may qualify as a therapeutic molecule in phenylketonuria.
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