Evidence map›Paper›PMID 24464190›Full record

ArticleInternational journal of epidemiology2014

Effect of secular trends on age-related trajectories of cardiovascular risk factors: the Whitehall II longitudinal study 1985-2009.

Adam Hulmán, Adam G Tabák, Tibor A Nyári, Dorte Vistisen, Mika Kivimäki, Eric J Brunner, Daniel R Witte

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of epidemiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 33 citations in OpenAlex.

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  11. Global epidemiology of dyslipidaemias.Nature reviews. Cardiology · 2021
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Adam HulmánDepartment of Medical Physics and Medical Informatics, University of Szeged, Szeged, Hungary, Department of Epidemiology and Public Health, University College London, London, UK, First Department of Medicine, Semmelweis University Faculty of Medicine, Budapest, Hungary, Steno Diabetes Center, Gentofte, Denmark and Centre de Recherche Public de la Santé, Strassen, Luxembourg hulman.adam@med.u-szeged.hu.
Adam G TabákDepartment of Medical Physics and Medical Informatics, University of Szeged, Szeged, Hungary, Department of Epidemiology and Public Health, University College London, London, UK, First Department of Medicine, Semmelweis University Faculty of Medicine, Budapest, Hungary, Steno Diabetes Center, Gentofte, Denmark and Centre de Recherche Public de la Santé, Strassen, LuxembourgDepartment of Medical Physics and Medical Informatics, University of Szeged, Szeged, Hungary, Department of Epidemiology and Public Health, University College London, London, UK, First Department of Medicine, Semmelweis University Faculty of Medicine, Budapest, Hungary, Steno Diabetes Center, Gentofte, Denmark and Centre de Recherche Public de la Santé, Strassen, Luxembourg.
Tibor A NyáriDepartment of Medical Physics and Medical Informatics, University of Szeged, Szeged, Hungary, Department of Epidemiology and Public Health, University College London, London, UK, First Department of Medicine, Semmelweis University Faculty of Medicine, Budapest, Hungary, Steno Diabetes Center, Gentofte, Denmark and Centre de Recherche Public de la Santé, Strassen, Luxembourg.
Dorte VistisenDepartment of Medical Physics and Medical Informatics, University of Szeged, Szeged, Hungary, Department of Epidemiology and Public Health, University College London, London, UK, First Department of Medicine, Semmelweis University Faculty of Medicine, Budapest, Hungary, Steno Diabetes Center, Gentofte, Denmark and Centre de Recherche Public de la Santé, Strassen, Luxembourg.
Mika KivimäkiDepartment of Medical Physics and Medical Informatics, University of Szeged, Szeged, Hungary, Department of Epidemiology and Public Health, University College London, London, UK, First Department of Medicine, Semmelweis University Faculty of Medicine, Budapest, Hungary, Steno Diabetes Center, Gentofte, Denmark and Centre de Recherche Public de la Santé, Strassen, Luxembourg.
Eric J BrunnerDepartment of Medical Physics and Medical Informatics, University of Szeged, Szeged, Hungary, Department of Epidemiology and Public Health, University College London, London, UK, First Department of Medicine, Semmelweis University Faculty of Medicine, Budapest, Hungary, Steno Diabetes Center, Gentofte, Denmark and Centre de Recherche Public de la Santé, Strassen, Luxembourg.
Daniel R WitteDepartment of Medical Physics and Medical Informatics, University of Szeged, Szeged, Hungary, Department of Epidemiology and Public Health, University College London, London, UK, First Department of Medicine, Semmelweis University Faculty of Medicine, Budapest, Hungary, Steno Diabetes Center, Gentofte, Denmark and Centre de Recherche Public de la Santé, Strassen, Luxembourg.
University of Szeged · HUUniversity College London · GB

Funding

Socio-economic status and heterogeneity in agingR01AG013196 · NIA · UNIVERSITY OF LONDON INST OF NEUROLOGY · PI MARMOT, MICHAEL G, SINGH-MANOUX, ARCHANA · 1996 to 2013
$3.5M
Socioeconomic gradient in CHD in early old ageR01HL036310 · NHLBI · UNIVERSITY OF LONDON · PI KIVIMAKI, MIKA J, MARMOT, MICHAEL G · 1986 to 2012
$3.1M
Health behaviors over the adult lifecourse and cognitive agingR01AG034454 · NIA · UNIVERSITY COLLEGE LONDON · PI KIVIMAKI, MIKA J, SINGH-MANOUX, ARCHANA · 2009 to 2013
$1.5M
British Heart Foundation RG/13/2/30098Medical Research Council K013351Medical Research Council MR/K013351/1NHLBI NIH HHS R01 HL036310NIA NIH HHS R01AG034454NIA NIH HHS R01AG13196
6 · The paper itself

Abstract

backgroundSecular trends in cardiovascular risk factors have been described, but few studies have examined simultaneously the effects of both ageing and secular trends within the same cohort.

methodsDevelopment of cardiovascular risk factors over the past three decades was analysed using serial measurements from 10 308 participants aged from 35 to 80 years over 25 years of follow-up from five clinical examination phases of the Whitehall II study. Changes of body mass index, waist circumference, blood pressure and total and high-density lipoprotein cholesterol distribution characteristics were analysed with quantile regression models in the 57-61 age group. Age-related trajectories of risk factors were assessed by fitting mixed-effects models with adjustment for year of birth to reveal secular trends.

resultsAverage body mass index and waist circumference increased faster with age in women than in men, but the unfavourable secular trend was more marked in men. Distributions showed a fattening of the right tail in each consecutive phase, meaning a stronger increase in higher percentiles. Despite the higher obesity levels in younger birth cohorts, total cholesterol decreased markedly in the 57-61 age group along the entire distribution rather than in higher extremes only.

conclusionThe past three decades brought strong and heterogeneous changes in cardiovascular risk factor distributions. Secular trends appear to modify age-related trajectories of cardiovascular risk factors, which may be a source of bias in longitudinal analyses.

Indexed as

AdultAgedAged, 80 and overAgingBlood PressureBody CompositionBody Mass IndexCardiovascular DiseasesFemaleHumansLipidsLongitudinal StudiesMaleMiddle AgedObesityRisk FactorsLipidsageingblood pressurecholesterolObesityquantile regressionsecular trend

Identifiers

PMID24464190
PMCPMC4052135
OpenAlexW2170963837

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.