ArticleNature immunology2014
K63-linked polyubiquitination of transcription factor IRF1 is essential for IL-1-induced production of chemokines CXCL10 and CCL5.
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Article in Nature immunology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers.
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82citing papers in PubMed
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82 citing papers in PubMed, 119 citations in OpenAlex.
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- Roles of Interferon Regulatory Factor 1 in Tumor Progression and Regression: Two Sides of a Coin.International journal of molecular sciences · 2024Review
- Decoding Ubiquitin Modifications by Mass Spectrometry.Advances in experimental medicine and biology · 2024Review
- The IRF1/GBP5 axis promotes osteoarthritis progression by activating chondrocyte pyroptosis.Journal of orthopaedic translation · 2024Article
- S1P/S1PR signaling pathway advancements in autoimmune diseases.Biomolecules & biomedicine · 2023Review
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- Differential regulation of BIRC2 and BIRC3 expression by inflammatory cytokines and glucocorticoids in pulmonary epithelial cells.PloS one · 2023Article
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- Nitric-oxide enriched plasma-activated water inactivates 229E coronavirus and alters antiviral response genes in human lung host cells.Bioactive materials · 2023Article
- Cellular inhibitor of apoptosis 2 (cIAP2) restricts neuroinflammation during experimental autoimmune encephalomyelitis.Journal of neuroinflammation · 2022Article
- Cytoplasmic and Nuclear Functions of cIAP1.Biomolecules · 2022Review
- hsa_circ_0003410 promotes hepatocellular carcinoma progression by increasing the ratio of M2/M1 macrophages through the miR-139-3p/CCL5 axis.Cancer science · 2022Article
22 more citing papers are in PubMed but not listed here.
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Authors and funding
18 authors at 3 institutions in 2 countries.
Kuzhuvelil B HarikumarDepartment of Biochemistry and Molecular Biology and the Massey Cancer Center, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA.
Jessie W YesterDepartment of Biochemistry and Molecular Biology and the Massey Cancer Center, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA.
Michael J SuraceDepartment of Biochemistry and Molecular Biology and the Massey Cancer Center, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA.
Clement OyeniranDepartment of Biochemistry and Molecular Biology and the Massey Cancer Center, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA.
Megan M PriceDepartment of Biochemistry and Molecular Biology and the Massey Cancer Center, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA.
Wei-Ching HuangDepartment of Biochemistry and Molecular Biology and the Massey Cancer Center, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA.
Nitai C HaitDepartment of Biochemistry and Molecular Biology and the Massey Cancer Center, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA.
Jeremy C AllegoodDepartment of Biochemistry and Molecular Biology and the Massey Cancer Center, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA.
Akimitsu Yamada1] Department of Biochemistry and Molecular Biology and the Massey Cancer Center, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA. [2] Department of Surgery and the Massey Cancer Center, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA.
Xiangqian KongState Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
Helen M LazearDepartment of Medicine, Department of Molecular Microbiology and Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, Missouri, USA.
Reetika BhardwajDepartment of Biochemistry and Molecular Biology and the Massey Cancer Center, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA.
Kazuaki Takabe1] Department of Biochemistry and Molecular Biology and the Massey Cancer Center, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA. [2] Department of Surgery and the Massey Cancer Center, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA.
Michael S DiamondDepartment of Medicine, Department of Molecular Microbiology and Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, Missouri, USA.
Cheng LuoState Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
Sheldon MilstienDepartment of Biochemistry and Molecular Biology and the Massey Cancer Center, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA.
Sarah SpiegelDepartment of Biochemistry and Molecular Biology and the Massey Cancer Center, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA.
Tomasz KordulaDepartment of Biochemistry and Molecular Biology and the Massey Cancer Center, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA.
Virginia Commonwealth University · USChinese Academy of Sciences · CNWashington University in St. Louis · US
Funding
Virus Vector Shared ResourceP30CA016059 · NCI · VIRGINIA COMMONWEALTH UNIVERSITY · PI Keri R Maher · 1985 to 2026
$51.0MThe Effect of Lyn Deficiency on Mast Cell Activation and Inflammatory Disease ProU19AI077435 · NIAID · VIRGINIA COMMONWEALTH UNIVERSITY · PI CONRAD, DANIEL H · 2008 to 2012
$7.7MVCU Neuroscience Center Core GrantP30NS047463 · NINDS · VIRGINIA COMMONWEALTH UNIVERSITY · PI POVLISHOCK, JOHN T · 2003 to 2013
$5.0MSPHINGOSINE AS A MODULATOR OF CELLULAR PROLIFERATIONR01GM043880 · NIGMS · VIRGINIA COMMONWEALTH UNIVERSITY · PI SPIEGEL, SARAH · 1990 to 2023
$3.8MSphingosine Kinases in Cancer Cell SignalingR01CA061774 · NCI · VIRGINIA COMMONWEALTH UNIVERSITY · PI SPIEGEL, SARAH · 1994 to 2015
$3.8MSphingosine-1 phosphate phosphohydrolaseR37GM043880 · NIGMS · VIRGINIA COMMONWEALTH UNIVERSITY · PI SPIEGEL, SARAH · 2003 to 2012
$3.2MTargeting sphingosine kinases in FceRI-mediated allergic responsesR01AI050094 · NIAID · VIRGINIA COMMONWEALTH UNIVERSITY · PI SPIEGEL, SARAH · 2002 to 2012
$2.9MNovel Functions of S1P in NeuroinflammationR01AI093718 · NIAID · VIRGINIA COMMONWEALTH UNIVERSITY · PI KORDULA, TOMASZ K · 2012 to 2016
$1.8MSphingosine-1 Phosphate in Breast Cancer Progression and LymphangiogenesisR01CA160688 · NCI · VIRGINIA COMMONWEALTH UNIVERSITY · PI TAKABE, KAZUAKI · 2012 to 2016
$1.5MNCI NIH HHS P30 CA016059NCI NIH HHS R01 CA061774NCI NIH HHS R01 CA160688NIAID NIH HHS R01 AI050094NIAID NIH HHS R01 AI093718NIAID NIH HHS U19 AI077435NIGMS NIH HHS R01 GM043880NIGMS NIH HHS R37 GM043880NINDS NIH HHS P30 NS047463
Abstract
Although interleukin 1 (IL-1) induces expression of the transcription factor IRF1 (interferon-regulatory factor 1), the roles of IRF1 in immune and inflammatory responses and mechanisms of its activation remain elusive. Here we found that IRF1 was essential for IL-1-induced expression of the chemokines CXCL10 and CCL5, which recruit mononuclear cells into sites of sterile inflammation. Newly synthesized IRF1 acquired Lys63 (K63)-linked polyubiquitination mediated by the apoptosis inhibitor cIAP2 that was enhanced by the bioactive lipid S1P. In response to IL-1, cIAP2 and the sphingosine kinase SphK1 (the enzyme that generates S1P) formed a complex with IRF1, which led to its activation. Thus, IL-1 triggered a hitherto unknown signaling cascade that controlled the induction of IRF1-dependent genes that encode molecules important for sterile inflammation.
Indexed as
AnimalsChemokine CCL5Chemokine CXCL10Chemotaxis, LeukocyteEnzyme-Linked Immunosorbent AssayHumansImmunoblottingImmunoprecipitationInflammationInterferon Regulatory Factor-1Interleukin-1Leukocytes, MononuclearLysineMiceMice, KnockoutReal-Time Polymerase Chain ReactionChemokine CCL5Chemokine CXCL10Interferon Regulatory Factor-1Interleukin-1IRF1 protein, humanIrf1 protein, mouseLysine
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