ArticleMolecular biology reports2014
Association of mutation and hypermethylation of p21 gene with susceptibility to breast cancer: a study from north India.
Article in Molecular biology reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8 citing papers in PubMed, 11 citations in OpenAlex.
- MDM2 and DNMT1 inhibitors induce neuroblastoma cell death through p53-dependent and independent pathways.Epigenomics · 2025Article
- Cajaninstilbene Acid and Its Derivative as Multi-Therapeutic Agents: A Comprehensive Review.Molecules (Basel, Switzerland) · 2024Review
- North India Cancer Risk: A Detailed Review with Focus on Jammu and Kashmir Demographics.Asian Pacific journal of cancer prevention : APJCP · 2024Review
- Anti-Proliferative Effect of Statins Is Mediated by DNMT1 Inhibition and p21 Expression in OSCC Cells.Cancers · 2020Article
- The Role of the Cyclin Dependent Kinase Inhibitor p21Cancers · 2019Review
- Bag-1 silencing enhanced chemotherapeutic drug-induced apoptosis in MCF-7 breast cancer cells affecting PI3K/Akt/mTOR and MAPK signaling pathways.Molecular biology reports · 2019Article
- Significant association of PRMT6 hypomethylation with colorectal cancer.Journal of clinical laboratory analysis · 2018Article
- Breast tumor DNA methylation patterns associated with smoking in the Carolina Breast Cancer Study.Breast cancer research and treatment · 2017Article
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Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
p21 gene located at chromosome 6p21.2 is a possible tumour suppressor gene involved in the pathogenesis of breast cancer. Both genetic and epigenetic alterations in p21 have been implicated in breast carcinoma. In the present study, our main aim was to study the impact of these two kinds of alterations of p21 gene in Indian female breast cancer patients. A total of 150 female breast cancer patients of north India were screened by PCR-SSCP followed by direct sequencing and methylation specific PCR. Mutational screening of p21 gene revealed significant amount of mutations [32.66% (49/150)] in exon 2, whereas p21 promoter was found hypermethylated in 42 of 150 (28%) breast cancer patients in our population. The intriguing feature of the study was the G>T transition (GAG>TAG) at codon 107 and the A>C transition (AGC>CGC) at codon 146 possibly rendering p21 completely ineffective in its anti- proliferative activity. Our results suggest a significant association between the mutational and hypermethylation profile of p21 gene. Therefore, we show for the first time that the significant association of p21 mutation and hypermethylation leads to the complete inactivation of p21 gene in Indian female breast cancer patients. Complete silencing of the p21 gene seems to be the result not only of genetic alterations but also of epigenetic modification.
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