SynthesisEuropean journal of pediatrics2014
Autism spectrum disorders in XYY syndrome: two new cases and systematic review of the literature.
Synthesis in European journal of pediatrics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 36 citations in OpenAlex.
- Characterization of autism spectrum disorder and neurodevelopmental profiles in youth with XYY syndrome.Journal of neurodevelopmental disorders · 2018Trial
- [Chronic venous leg ulcers in association with postthrombotic syndrome in an XYY patient with a history of estrogen therapy].Dermatologie (Heidelberg, Germany) · 2023Article
- Missing from the Narrative: A Seven-Decade Scoping Review of the Inclusion of Black Autistic Women and Girls in Autism Research.Behavior analysis in practice · 2022Article
- Y chromosome gene copy number and lack of autism phenotype in a male with an isodicentric Y chromosome and absent NLGN4Y expression.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2019Article
- Rare 48, XYYY syndrome: case report and review of the literature.Clinical case reports · 2018Article
- Klinefelter syndrome and 47,XYY syndrome in children with B cell acute lymphoblastic leukaemia.British journal of haematology · 2017Review
- Duplication of Yq- and proximal Yp-arms with deletion of almost all PAR1 (including SHOX) in a young man with non-obstructive azoospermia, short stature and skeletal defects.Journal of applied genetics · 2017Article
- High resolution analysis of rare copy number variants in patients with autism spectrum disorder from Taiwan.Scientific reports · 2017Article
- Autism spectrum disorder associated with 49,XYYYY: case report and review of the literature.BMC medical genetics · 2017Review
- Sex chromosome abnormalities and psychiatric diseases.Oncotarget · 2017Review
- XYY syndrome: a 13-year-old boy with tall stature.Annals of pediatric endocrinology & metabolism · 2015Article
- Behavioral phenotypes in males with XYY and possible role of increased NLGN4Y expression in autism features.Genes, brain, and behavior · 2015Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelledAbnormalities of the sex chromosomes (47, XXY, 47 XYY, 45,X/46,XY mosaicism) are frequently associated with Autism Spectrum Disorders (ASD), but the male predisposition to these disorders has not been clearly explained. Previously, the role of the X chromosome was considered important in the ASD mainly because autistic symptoms were detected in genetic syndromes involving X chromosome (fragile X syndrome, Rett syndrome, Klinefelter syndrome). Instead, few studies have analyzed the possible role of the Y chromosome in the ASD. This study explores the role of the Y chromosome in ASD through a systematic literature review about the association between ASD and XYY syndrome and a description of two new cases with this association. The literature review considered studies published in peer-reviewed journals, included in the MEDLINE and PubMed databases, that examined the association between ASD and XYY syndrome. Few studies reported the occurrence of ASD in children with XYY karyotype and the majority of them did not reported a well-defined autism diagnostic category associated with an extra Y chromosome, but several clinical conditions that are generically described as language and social impairment.
conclusionThis study underlines the underestimated role of the Y chromosome in ASD, and we postulate that all the ASD associated with the XYY karyotype may presumably fall within mild degree of ASD as in our cases.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.