ArticleScientific reports2014
In vivo imaging of kidney glomeruli transplanted into the anterior chamber of the mouse eye.
Article in Scientific reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- The anterior chamber of the eye technology and its anatomical, optical, and immunological bases.Physiological reviews · 2024Review
- Fluorescence Angiography with Dual Fluorescence for the Early Detection and Longitudinal Quantitation of Vascular Leakage in Retinopathy.Biomedicines · 2023Article
- The Anterior Eye Chamber as a Visible Medium for In Vivo Tumorigenicity Tests.Stem cells translational medicine · 2022Article
- Noninvasive intravital high-resolution imaging of pancreatic neuroendocrine tumours.Scientific reports · 2019Article
- The eye as a novel imaging site in diabetes research.Pharmacology & therapeutics · 2019Review
- IntraocularMolecular metabolism · 2017Review
- Iris reconstruction using autologous iris preserved in cold balanced salt solution for 8 hours in iatrogenic total iridodialysis during cataract surgery: a case report.BMC ophthalmology · 2017Article
- Intravital imaging in the kidney.Current opinion in nephrology and hypertension · 2016Review
- In vivo microscopy.Nephrologie & therapeutique · 2016Review
- Tissue-Engineered Microvasculature to Reperfuse Isolated Renal Glomeruli.Tissue engineering. Part A · 2015Article
- Novel in vivo techniques to visualize kidney anatomy and function.Kidney international · 2015Review
- Defective podocyte insulin signalling through p85-XBP1 promotes ATF6-dependent maladaptive ER-stress response in diabetic nephropathy.Nature communications · 2015Article
- The lymph node as a new site for kidney organogenesis.Stem cells translational medicine · 2015Article
- Podocytes … What's Under Yours? (Podocytes and Foot Processes and How They Change in Nephropathy).Frontiers in endocrinology · 2015Review
- Intracameral Microimaging of Maturation of Human iPSC Derivatives into Islet Endocrine Cells.Cell transplantationArticle
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Multiphoton microscopy enables live imaging of the renal glomerulus. However, repeated in vivo imaging of the same glomerulus over extended periods of time and the study of glomerular function independent of parietal epithelial and proximal tubular cell effects has not been possible so far. Here, we report a novel approach for non-invasive imaging of acapsular glomeruli transplanted into the anterior chamber of the mouse eye. After microinjection, glomeruli were capable of engrafting on the highly vascularized iris. Glomerular structure was preserved, as demonstrated by podocyte specific expression of cyan fluorescent protein and by electron microscopy. Injection of fluorescence-labeled dextrans of various molecular weights allowed visualization of glomerular filtration and revealed leakage of 70 kDa dextran in an inducible model of proteinuria. Our findings demonstrate functionality and long-term survival of glomeruli devoid of Bowman's capsule and provide a novel approach for non-invasive longitudinal in vivo study of glomerular physiology and pathophysiology.
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