ArticleIndustrial health2014
Serum levels of TGF-β1 and MCP-1 as biomarkers for progressive coal workers' pneumoconiosis in retired coal workers: a three-year follow-up study.
Article in Industrial health, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 22 citations in OpenAlex.
- Research on the Prediction of Coal Workers' Pneumoconiosis Based on Easily Detectable Clinical Data: Machine Learning Model Development and Validation Study.JMIR medical informatics · 2026Article
- Development of a machine learning-based risk prediction model for early-stage pneumoconiosis: a retrospective study.Frontiers in medicine · 2025Article
- Plasma Cytokine Profiling Reveals Differences between Silicotic Patients with Simple Silicosis and Those with Progressive Massive Fibrosis Caused by Engineered Stone.International journal of molecular sciences · 2023Article
- Postexposure progression of pneumoconiosis among former Appalachian coal miners.American journal of industrial medicine · 2022Article
- Serum levels of inflammatory mediators as prognostic biomarker in silica exposed workers.Scientific reports · 2021Article
- Pneumoconiosis progression patterns in US coal miner participants of a job transfer programme designed to prevent progression of disease.Occupational and environmental medicine · 2020Article
- Effects of Dust Storm Fine Particle-Inhalation on the Respiratory, Cardiovascular, Endocrine, Hematological, and Digestive Systems of Rats.Chinese medical journal · 2018Article
- Cross-section analysis of coal workers' pneumoconiosis and higher brachial-ankle pulse wave velocity within Kailuan study.BMC public health · 2017Article
- IL-10-Producing CD1dFrontiers in immunology · 2017Article
- Differential gene expression associated with inflammation in peripheral blood cells of patients with pneumoconiosis.Journal of occupational health · 2016Article
- Pneumoconiosis increases the risk of congestive heart failure: A nationwide population-based cohort study.Medicine · 2016Article
- Prevalence Characteristics of Coal Workers' Pneumoconiosis (CWP) in a State-Owned Mine in Eastern China.International journal of environmental research and public health · 2015Article
- Machine learning prediction of coal workers' pneumoconiosis classification based on few-shot clinical data.Digital healthArticle
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Various cytokines activated by the inhalation of coal dust may mediate inflammation and lead to tissue damage. Objective of this study was to examine the relationships between coal workers' pneumoconiosis (CWP) progression over a 3 yr period and the serum levels of cytokines in 85 retired coal workers. To investigate the relevance of serum cytokines in CWP, serum levels of interleukin-8 (IL-8), tumor necrosis factor-alpha (TNF-α), transforming growth factor-beta1 (TGF-β1), and monocyte chemotactic protein-1 (MCP-1) as progressive CWP biomarkers were studied in relation to the progression of pneumoconiosis over a 3 yr period in 85 patients with CWP. CWP progression was evaluated through paired comparisons of chest radiographs. Median levels of TGF-β1 and MCP-1 were significantly higher in subjects with progressive CWP than in those without CWP progression. The area under the ROC curve for TGF-β1 (0.693) and MCP-1 (0.653) indicated that these cytokines could serve as biomarkers for the progression of CWP. Serum TGF-β1 levels were related to the progression of CWP (β=0.247, p=0.016). The results suggest that high serum levels of TGF-β1 and MCP-1 are associated with the progression of CWP.
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