ArticleHeart and vessels2015
Serum cholinesterase is an important prognostic factor in chronic heart failure.
Article in Heart and vessels, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 39 citations in OpenAlex.
- Associations between baseline cerebral oxygen saturation, preoperative B-type natriuretic peptide and hemoglobin levels, and mortality after cardiac surgery in non-dialysis patients.Journal of clinical monitoring and computing · 2025Article
- Measurement of acetylcholinesterase activity by electrochemical analysis method utilizing organocatalytic reactions.RSC advances · 2025Article
- Prediction of prognosis in elderly patients with chronic heart failure based on random survival forest.Frontiers in cardiovascular medicine · 2025Article
- Butyrylcholinesterase and 24 h-urinary copper excretion as compliance assessment in long-term treated Wilson's disease.Frontiers in neurology · 2025Article
- Development and validation of a multifactorial nomogram to predict 48 month mortality in decompensated heart failure.ESC heart failure · 2024Article
- Use of the Serum Level of Cholinesterase as a Prognostic Marker of Nonfatal Clinical Outcomes in Patients Hospitalized with Acute Exacerbations of Chronic Obstructive Pulmonary Disease.Canadian respiratory journal · 2024Article
- Pseudocholinesterase as a Biomarker for Untreated Wilson's Disease.Biomolecules · 2022Article
- Cholinesterase Deficiency Syndrome-A Pitfall in the Use of Butyrylcholinesterase as a Biomarker for Wilson's Disease.Biomolecules · 2022Article
- Clinical Impact of Measures for Frailty Severity in Poor-Risk Patients Undergoing Revascularization for Chronic Limb-Threatening Ischemia.Journal of atherosclerosis and thrombosis · 2022Observational
- Article
- Influence of Serum Cholinesterase Levels on Patients Suspected of Having Stable Coronary Artery Disease.Internal medicine (Tokyo, Japan) · 2021Article
- Cholinesterase: Conflicting Aspects of Two Cardiovascular Diseases.Internal medicine (Tokyo, Japan) · 2021Article
- Admission serum cholinesterase concentration for prediction of in-hospital mortality in very elderly patients with acute ischemic stroke: a retrospective study.Aging clinical and experimental research · 2020Article
- Article
- Prognostic Significance of Serum Cholinesterase Level in Patients With Acute Decompensated Heart Failure With Preserved Ejection Fraction: Insights From the PURSUIT-HFpEF Registry.Journal of the American Heart Association · 2020Observational
- Low serum cholinesterase predicts complication risk after orthopedic surgery in elderly patients: an observational pilot study.JA clinical reports · 2019Article
- Increased serum Wisteria floribunda agglutinin positive Mac-2 binding protein (Mac-2 binding protein glycosylation isomer) in chronic heart failure: a pilot study.Heart and vessels · 2018Article
- Intracardiac impedance after cardiac resynchronization therapy is a novel predictor for worsening of heart failure.Heart and vessels · 2017Article
- Mid-term survival after continuous-flow left ventricular assist device versus heart transplantation.Heart and vessels · 2016Article
- Additive clinical value of serum brain-derived neurotrophic factor for prediction of chronic heart failure outcome.Heart and vessels · 2016Article
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We determine the importance of indicators of nutrition including lymphocyte, total protein, albumin, cholinesterase and body mass index, and compare the prognostic significance in chronic heart failure (CHF). We examined consecutive 465 CHF patients (376 males, age 62 ± 14 years) who underwent cardiopulmonary exercise testing, echocardiography and blood examination including indicators of nutrition at the same time in our hospital. The patients were followed up [median period 766 days (interquartile range 500-1060)] to register cardiac deaths and rehospitalization due to worsening heart failure. There were 180 cardiac events during the follow-up periods. Patients with cardiac events had lower cholinesterase level than those without events (P < 0.001). On the receiver operating characteristic analysis, the best cut-off value for cholinesterase was 240 U/l (area under the curve 0.720). In the Kaplan-Meier analysis, patients with cholinesterase <240 U/l had significantly higher cardiac event rates than those with cholinesterase >240 U/l. Multivariable Cox proportional hazards model demonstrated that NYHA class III [hazard ratio (HR): 1.688, 95 % confidence interval (CI) 1.062-2.684, P = 0.027], eGFR (HR: 0.983, 95 % CI 0.971-0.995, P = 0.006), sodium concentration (HR: 0.947, 95 % CI 0.897-0.999, P < 0.046), log BNP (HR: 1.880, 95 % CI 1.509-2.341, P < 0.001), cholinesterase (HR: 0.996, 95 % CI 0.993-0.998, P = 0.002) and exertional periodic breathing (HR: 1.619, 95 % CI 1.098-2.388, P = 0.015) were independent factors to predict adverse clinical outcomes. Serum cholinesterase level was an important prognostic factor in CHF.
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