ArticleCancer causes & control : CCC2014
Urinary lignans and inflammatory markers in the US National Health and Nutrition Examination Survey (NHANES) 1999-2004 and 2005-2008.
Article in Cancer causes & control : CCC, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 32 citations in OpenAlex.
- Investigating zinc's role in mitigating blood lead levels' toxicity on gut microbiota diversity: NHANES 2007-2010.Toxicology letters · 2025Article
- Urinary enterolignan concentrations and cardiometabolic risk biomarkers in pregnant US women.Nutrition journal · 2025Article
- Elevated urinary phytoestrogens are associated with delayed biological aging: a cross-sectional analysis of NHANES data.Scientific reports · 2025Article
- The cross-sectional correlation between the oxidative balance score and cardiometabolic risk factors and its potential correlation with longitudinal mortality in patients with cardiometabolic risk factors.BMC public health · 2024Article
- Alteration of intestinal microbiota is associated with diabetic retinopathy and its severity: Samples collected from southeast coast Chinese.World journal of diabetes · 2023Article
- Interplay between Lignans and Gut Microbiota: Nutritional, Functional and Methodological Aspects.Molecules (Basel, Switzerland) · 2023Review
- Lignan exposure: a worldwide perspective.European journal of nutrition · 2022Review
- Origin of Wine Lignans.Plant foods for human nutrition (Dordrecht, Netherlands) · 2021Article
- Dietary Phytoestrogens and Their Metabolites as Epigenetic Modulators with Impact on Human Health.Antioxidants (Basel, Switzerland) · 2021Review
- Do Bioactive Food Compound withNutrients · 2021Review
- Naturally Lignan-Rich Foods: A Dietary Tool for Health Promotion?Molecules (Basel, Switzerland) · 2019Review
- Self-reported dietary flavonoid intake and serum markers of inflammation: the multiethnic cohort.Cancer causes & control : CCC · 2018Article
- Dietary Polyphenols, Mediterranean Diet, Prediabetes, and Type 2 Diabetes: A Narrative Review of the Evidence.Oxidative medicine and cellular longevity · 2017Review
- Urinary phytoestrogens and cancer, cardiovascular, and all-cause mortality in the continuous National Health and Nutrition Examination Survey.European journal of nutrition · 2016Article
- Enterolignan-producing phenotypes are associated with increased gut microbial diversity and altered composition in premenopausal women in the United States.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2015Article
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6 authors at 5 institutions in 3 countries.
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Abstract
purposeChronic inflammation has been implicated in the etiology of various chronic diseases. We previously found that certain urinary isoflavones are associated with markers of inflammation. In the present study, we examined the associations of serum C-reactive protein (CRP) and white blood cell (WBC) count with lignans, which are more frequent in the Western diet than isoflavones.
methodsOur analysis included 2,028 participants of NHANES 2005-2008 and 2,628 participants of NHANES 1999-2004 aged 18 years and older. The exposures of interest were urinary mammalian lignans (enterodiol and enterolactone). Outcome variables were two inflammatory markers (CRP [≤10 mg/L] and WBC [≥3.0 and ≤11.7 (1,000 cells/μL)]). Log-transformed CRP concentration and WBC count by log-transformed creatinine-standardized concentrations of mammalian lignans were used for linear regression.
resultsStatistically significant inverse associations of urinary lignan, enterodiol, and enterolactone concentrations with circulating CRP and WBC counts were observed in the multivariate-adjusted models: In NHANES 2005-2008, per one-percent increase in lignan concentrations in the urine, CRP concentrations and WBC counts decreased by 8.1 % (95 % CI -11.5, -4.5) and 1.9 % (95 % CI -2.7; -1.2), respectively. Per one-percent increase in enterodiol and enterolactone, WBC counts decreased by 2.1 % (95 % CI -2.8, -1.3) and 1.3 % (95 % CI -1.9, -0.6), respectively. In NHANES 1999-2004, analogous results were 3.0 % (95 % CI -5.6, -0.3), 1.2 % (95 % CI -2.0; -0.4), 1.0 % (95 % CI -1.8, -0.2), and 0.8 % (95 % CI -1.4, 0.2).
conclusionsMammalian lignans were inversely associated with markers of chronic inflammation. Due to the cross-sectional design, our findings require confirmation in prospective studies.
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