ArticleObstetrics and gynecology2014
Ovarian cancer rates after hysterectomy with and without salpingo-oophorectomy.
Article in Obstetrics and gynecology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 32 citations in OpenAlex.
- Menopausal Estrogen-Alone Therapy and Health Outcomes in Women With and Without Bilateral Oophorectomy: A Randomized Trial.Annals of internal medicine · 2019Trial
- Premenopausal bilateral oophorectomy leads to steeper declines in gray matter volume and alterations in perfusion and brain bioenergetics.Scientific reports · 2026Article
- Effect of hysterectomy on the risk of ovarian cancer: A South Korean national cohort study.PloS one · 2026Article
- The potential for opportunistic salpingectomy to reduce ovarian cancer in women undergoing non-gynecologic surgery.Gynecologic oncology reports · 2025Article
- Long-term outcomes of bilateral salpingo-oophorectomy in women with personal history of breast cancer.BMJ oncology · 2025Article
- Bilateral Oophorectomy Prevalence Among U.S. Women.Journal of women's health (2002) · 2024Article
- Risks of Stroke and Heart Disease Following Hysterectomy and Oophorectomy in Chinese Premenopausal Women.Stroke · 2022Article
- Ovarian metastases in young women with colorectal cancer: a retrospective multicenter cohort study.International journal of colorectal disease · 2022Article
- Surgically Induced Menopause-A Practical Review of Literature.Medicina (Kaunas, Lithuania) · 2019Review
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Authors and funding
7 authors at 1 institution in 2 countries.
Funding
Abstract
objectiveTo estimate ovarian and peritoneal cancer rates after hysterectomy with and without salpingo-oophorectomy for benign conditions.
methodsAll patients after hysterectomy for benign disease from 1988 to 2006 in Kaiser Permanente Northern California, an integrated health organization. Incidence rates per 100,000 person-years were calculated.
resultsOf 56,692 patients, the majority (54%) underwent hysterectomy with bilateral salpingo-oophorectomy; 7% had hysterectomy with unilateral salpingo-oophorectomy, and 39% had hysterectomy alone. There were 40 ovarian and eight peritoneal cancers diagnosed during follow-up. Median age at ovarian and peritoneal cancer diagnosis was 50 and 64 years, respectively. Age-standardized rates (per 100,000 person-years) of ovarian or peritoneal cancer were 26.7 (95% confidence interval [CI] 16-37.5) for those with hysterectomy alone, 22.8 (95% CI 0.0-46.8) for hysterectomy and unilateral salpingo-oophorectomy, and 3.9 (95% CI 1.5-6.4) for hysterectomy and bilateral salpingo-oophorectomy. Rates of ovarian cancer were 26.2 (95% CI 15.5-37) for those with hysterectomy alone, 17.5 (95% CI 0.0-39.1) for hysterectomy and unilateral salpingo-oophorectomy, and 1.7 (95% CI 0.4-3) for those with hysterectomy and bilateral salpingo-oophorectomy. Compared with women undergoing hysterectomy alone, those receiving an unilateral salpingo-oophorectomy had a hazard ratio (HR) for ovarian cancer of 0.58 (95% CI 0.18-1.9) and those undergoing bilateral salpingo-oophorectomy had an HR of 0.12 (95% CI 0.05-0.28).
conclusionsThe removal of both ovaries decreases the incidence of ovarian and peritoneal cancers. Removal of one ovary might also decrease the incidence of ovarian cancer but warrants further investigation. LEVEL OF EVIDENCE: II.
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