Trial reportObstetrics and gynecology2014
Maternal vitamin D status and small-for-gestational-age offspring in women at high risk for preeclampsia.
Trial report in Obstetrics and gynecology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03087149 (Supplementation of Vitamin D in Preterm Infants- Monitored Therapy vs Standard Therapy. A Randomized Controlled Trial), which is not on this map. Cited by 39 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Supplementation of Vitamin D in Preterm Infants- Monitored Therapy vs Standard Therapy. A Randomized Controlled Trial
Who cites it
39 citing papers in PubMed, 5 syntheses or guidelines pooled it, 81 citations in OpenAlex.
- The effect of vitamin D deficiency during pregnancy on adverse birth outcomes in neonates: a systematic review and meta-analysis.Frontiers in pediatrics · 2024Pooled it
- Effect of maternal vitamin D status on risk of adverse birth outcomes: a systematic review and dose-response meta-analysis of observational studies.European journal of nutrition · 2022Pooled it
- The Gestational Effects of Maternal Bone Marker Molecules on Fetal Growth, Metabolism and Long-Term Metabolic Health: A Systematic Review.International journal of molecular sciences · 2022Pooled it
- Predictors of Adverse Pregnancy Outcomes in Pregnant Women Living with Obesity: A Systematic Review.International journal of environmental research and public health · 2022Pooled it
- Vitamin D metabolites across the menstrual cycle: a systematic review.BMC women's health · 2019Pooled it
- Early pregnancy vitamin D status and risk for adverse maternal and infant outcomes in a bi-ethnic cohort: the Behaviors Affecting Baby and You (B.A.B.Y.) Study.The British journal of nutrition · 2015Trial
- Molecular pathways in placental-fetal development and disruption.Molecular and cellular endocrinology · 2024Review
- Early pregnancy vitamin D status and risk of select congenital anomalies in the National Birth Defects Prevention Study.Birth defects research · 2023Article
- Review: Influence of 25(OH)D Blood Concentration and Supplementation during Pregnancy on Preeclampsia Development and Neonatal Outcomes.International journal of molecular sciences · 2022Review
- Associations between maternal vitamin D status and porcine litter characteristics throughout gestation.Journal of animal science and biotechnology · 2022Article
- Effects of exogenous progesterone on the expression of mineral regulatory molecules by ovine endometrium and placentomes†.Biology of reproduction · 2022Article
- Effects of progesterone and interferon tau on ovine endometrial phosphate, calcium, and vitamin D signaling†.Biology of reproduction · 2022Article
- Phosphate, Calcium, and Vitamin D: Key Regulators of Fetal and Placental Development in Mammals.Advances in experimental medicine and biology · 2022Review
- The role of vitamin D in perinatology. An up-to-date review.Archives of medical science : AMS · 2021Article
- 25-Hydroxyvitamin D profiles and maternal bone mass during pregnancy and lactation in Japanese women.Journal of bone and mineral metabolism · 2020Article
- Vitamin D Promotes Trophoblast Cell Induced Separation of Vascular Smooth Muscle Cells in Vascular RemodelingFrontiers in cell and developmental biology · 2020Article
- New Approaches to Fetal Growth Restriction: The Time for Metabolomics Has Come.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2019Review
- Third Trimester Vitamin D Status Is Associated With Birth Outcomes and Linear Growth of HIV-Exposed Uninfected Infants in the United States.Journal of acquired immune deficiency syndromes (1999) · 2019Article
- Maternal Vitamin D Deficiency and the Risk of Small for Gestational Age: A Meta-analysis.Iranian journal of public health · 2018Review
- Maternal Anthropometry and Its Relationship with the Nutritional Status of Vitamin D, Calcium, and Parathyroid Hormone in Pregnant Women After Roux-en-Y Gastric Bypass.Obesity surgery · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveTo examine the association between second-trimester maternal serum 25-hydroxyvitamin D concentrations and risk of small for gestational age (SGA) in singleton live births.
methodsWe assayed serum samples at 12-26 weeks of gestation for 25-hydroxyvitamin D in a sample of participants in a multicenter clinical trial of low-dose aspirin for the prevention of preeclampsia in high-risk women (n=792). Multivariable log-binomial regression models were used to assess the association between 25-hydroxyvitamin D and risk of SGA (birth weight less than the 10 percentile for gestational age) after adjustment for confounders including maternal prepregnancy obesity, race, treatment allocation, and risk group.
resultsThirteen percent of neonates were SGA at birth. Mean (standard deviation) 25-hydroxyvitamin D concentrations were lower in women who delivered SGA (57.9 [29.9] nmol/L) compared with non-SGA neonates (64.8 [29.3] nmol/L, P=.028). In adjusted models, 25-hydroxyvitamin D concentrations of 50-74 nmol/L and 75 nmol/L or greater compared with less than 30 nmol/L were associated with 43% (95% confidence interval [CI] 0.33-0.99) and 54% (95% CI 0.24-0.87) reductions in risk of SGA, respectively. Race and maternal obesity each modified this association. White women with 25-hydroxyvitamin D 50 nmol/L or greater compared with less than 50 nmol/L had a 68% reduction in SGA risk (adjusted risk ratio 0.32, 95% CI 0.17-0.63) and nonobese women with 25-hydroxyvitamin D 50 nmol/L or greater compared with less than 50 nmol/L had a 50% reduction in SGA risk (adjusted risk ratio 0.50, 95% CI 0.31-0.82). There was no association between 25-hydroxyvitamin D and risk of SGA in black or obese mothers.
conclusionMaternal vitamin D status in the second trimester is associated with risk of SGA among all women and in the subgroups of white and nonobese women. LEVEL OF EVIDENCE: II.
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Registered trials
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