ReviewCurrent opinion in genetics & development2014
Histone variants: the tricksters of the chromatin world.
Review in Current opinion in genetics & development, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 49 citations in OpenAlex.
- Article
- Histone variants H3.3 and H2A.Z/H3.3 facilitate excision of uracil from nucleosome core particles.DNA repair · 2022Article
- Crystal and solution structures reveal oligomerization of individual capsid homology domains of Drosophila Arc.PloS one · 2021Article
- Histone variant MacroH2A1 is downregulated in prostate cancer and influences malignant cell phenotype.Cancer cell international · 2019Article
- H1.0 Linker Histone as an Epigenetic Regulator of Cell Proliferation and Differentiation.Genes · 2018Review
- Histone H2AX deficiency causes neurobehavioral deficits and impaired redox homeostasis.Nature communications · 2018Article
- Epigenetic mechanisms underlying nervous system diseases.Handbook of clinical neurology · 2018Review
- A journey through the microscopic ages of DNA replication.Protoplasma · 2017Review
- Promiscuous Histone Mis-Assembly Is Actively Prevented by Chaperones.Journal of the American Chemical Society · 2016Article
- Structural and biochemical analyses of monoubiquitinated human histones H2B and H4.Open biology · 2016Article
- The histone variant H2A.X is a regulator of the epithelial-mesenchymal transition.Nature communications · 2016Article
- Review
- Crystal structure and stable property of the cancer-associated heterotypic nucleosome containing CENP-A and H3.3.Scientific reports · 2014Article
- An evolving view of epigenetic complexity in the brain.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2014Review
- The histone variant MacroH2A1 regulates target gene expression in part by recruiting the transcriptional coregulator PELP1.Molecular and cellular biology · 2014Article
- Footprints of the sun: memory of UV and light stress in plants.Frontiers in plant science · 2014Review
- Histone-modifying enzymes, histone modifications and histone chaperones in nucleosome assembly: Lessons learned from Rtt109 histone acetyltransferases.Critical reviews in biochemistry and molecular biologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The eukaryotic genome exists in vivo at an equimolar ratio with histones, thus forming a polymer composed of DNA and histone proteins. Each nucleosomal unit in this polymer provides versatile capabilities and dynamic range. Substitutions of the individual components of the histone core with structurally distinct histone variants and covalent modifications alter the local fabric of the chromatin fiber, resulting in epigenetic changes that can be regulated by the cell. In this review, we highlight recent advances in the study of histone variant structure, assembly, and inheritance, their influence on nucleosome positioning, and their cumulative effect upon gene expression, DNA repair and the progression of disease. We also highlight fundamental questions that remain unanswered regarding the behavior of histone variants and their influence on cellular function in the normal and diseased states.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.