ReviewCurrent opinion in obstetrics & gynecology2014
Antenatal steroids: can we optimize the dose?
Review in Current opinion in obstetrics & gynecology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 43 citations in OpenAlex.
- The shifting landscape of the preterm brain.Neuron · 2025Review
- Frontiers in the Etiology and Treatment of Preterm Premature Rupture of Membrane: From Molecular Mechanisms to Innovative Therapeutic Strategies.Reproductive sciences (Thousand Oaks, Calif.) · 2024Review
- Association between betamethasone levels and respiratory distress syndrome in preterm births: A prospective cohort study.Clinical and translational science · 2022Article
- Should the interval between doses of antenatal corticosteroids be shortened in certain cases? Factors predicting preterm delivery < 48 h from presentation.Archives of gynecology and obstetrics · 2021Article
- Comparison of survival of preterm newborn rabbits at 25-28 days of gestation with perinatal therapies at birth transition.Journal of applied physiology (Bethesda, Md. : 1985) · 2021Article
- Single-course antenatal corticosteroids is related to faster growth in very-low-birth-weight infant.BMC pregnancy and childbirth · 2021Article
- Glycemia after Betamethasone in Pregnant Women without Diabetes-Impact of Marginal Values in the 75-g OGTT.Healthcare (Basel, Switzerland) · 2020Article
- Neonatal Morbidities of Fetal Growth Restriction: Pathophysiology and Impact.Frontiers in endocrinology · 2019Review
- A novel method for assessing cerebral autoregulation in preterm infants using transfer function analysis.Pediatric research · 2016Article
- Fatigue and breathlessness in pregnancy: a rare and sinister cause.BMJ case reports · 2014Article
- SARS-CoV-2 infection and glucose homeostasis in pregnancy. What about antenatal corticosteroids?Diabetes & metabolic syndromeReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purpose of reviewThe beneficial effects of antenatal steroids in women at risk of preterm birth are evident. A dose of 24 mg appears sufficient, but there are insufficient data to recommend betamethasone or dexamethasone, a single steroid dose, the optimal interval between doses and repeated courses, the gestational age at which treatment is beneficial and the long-term effects of steroid treatment. This review addresses these aspects of antenatal steroid treatment. RECENT
findingsAlthough the 12-h and 24-h dosing intervals are equivalent with respect to prevention of respiratory distress syndrome, the former enables the completion of treatment in 50% more neonates delivered prematurely. Reducing the single steroid dose in patients at risk for premature birth reduces the associated maternal side effects. An inverse relationship has been demonstrated between the number of corticosteroid courses and foetal growth. The reduced size of exposed foetuses has been attributed to birth at earlier gestational ages and decreased foetal growth. Evidence suggests that antenatal exposure to synthetic glucocorticoids in term-born children has long-lasting effects, which may have important implications in the recommendation of steroids before elective caesarean at term. SUMMARY: The short-term and long-term effects of the dosage regimen on the pregnant mother and foetus remain unclear.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.