Evidence map›Paper›PMID 24463066›Full record

ReviewActa biomaterialia2014

Learning from nature - novel synthetic biology approaches for biomaterial design.

Anton V Bryksin, Ashley C Brown, Michael M Baksh, M G Finn, Thomas H Barker

Abstract readReview
In one paragraph

Review in Acta biomaterialia, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Review
  6. Nature-Inspired Designs in Wind Energy: A Review.Biomimetics (Basel, Switzerland) · 2024
    Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Bioengineering of spider silks for the production of biomedical materials.Frontiers in bioengineering and biotechnology · 2022
    Review
  12. Review
  13. Review
  14. Article
  15. Article
  16. Kidney regeneration approaches for translation.World journal of urology · 2020
    Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Anton V BryksinWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, 313 Ferst Drive, Atlanta, GA 30332-0535, USA.
Ashley C BrownWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, 313 Ferst Drive, Atlanta, GA 30332-0535, USA; School of Chemistry & Biochemistry, Georgia Institute of Technology, Atlanta, GA, USA; School of Biology, Georgia Institute of Technology, Atlanta, GA, USA.
Michael M BakshSchool of Chemistry & Biochemistry, Georgia Institute of Technology, Atlanta, GA, USA; School of Biology, Georgia Institute of Technology, Atlanta, GA, USA.
M G FinnSchool of Chemistry & Biochemistry, Georgia Institute of Technology, Atlanta, GA, USA; School of Biology, Georgia Institute of Technology, Atlanta, GA, USA.
Thomas H BarkerWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, 313 Ferst Drive, Atlanta, GA 30332-0535, USA. Electronic address: thomas.barker@bme.gatech.edu.

Funding

Engineering fibrin polymers for enhanced angiogenesisR01EB011566 · NIBIB · GEORGIA INSTITUTE OF TECHNOLOGY · PI BARKER, THOMAS HARRISON · 2010 to 2013
$1.5M
Structural Relay Methods for Functional Peptide DiscoveryR21EB015663 · NIBIB · SCRIPPS RESEARCH INSTITUTE, THE · PI FINN, M.G., ORDOUKHANIAN, PHILLIP TODD · 2012 to 2013
$460k
Regulating fibrin polymerization through engineered thermo-responsive knob-pocketR21EB008463 · NIBIB · GEORGIA INSTITUTE OF TECHNOLOGY · PI BARKER, THOMAS HARRISON · 2008 to 2009
$421k
Fibrinogen-Triggered Matrix Assembly from Designed Peptide-Polymer ConjugatesR21EB013743 · NIBIB · GEORGIA INSTITUTE OF TECHNOLOGY · PI BARKER, THOMAS HARRISON, LYON, LOUIS ANDREW · 2012 to 2013
$384k
NIBIB NIH HHS R01 EB011566NIBIB NIH HHS R01EB011566NIBIB NIH HHS R21 EB008463NIBIB NIH HHS R21 EB013743NIBIB NIH HHS R21EB013743NIBIB NIH HHS R21 EB015663NIBIB NIH HHS R21EB015663
6 · The paper itself

Abstract

Many biomaterials constructed today are complex chemical structures that incorporate biologically active components derived from nature, but the field can still be said to be in its infancy. The need for materials that bring sophisticated properties of structure, dynamics and function to medical and non-medical applications will only grow. Increasing appreciation of the functionality of biological systems has caused biomaterials researchers to consider nature for design inspiration, and many examples exist of the use of biomolecular motifs. Yet evolution, nature's only engine for the creation of new designs, has been largely ignored by the biomaterials community. Molecular evolution is an emerging tool that enables one to apply nature's engineering principles to non-natural situations using variation and selection. The purpose of this review is to highlight the most recent advances in the use of molecular evolution in synthetic biology applications for biomaterial engineering, and to discuss some of the areas in which this approach may be successfully applied in the future.

Indexed as

Biocompatible MaterialsPolymersSynthetic BiologyTissue ScaffoldsVirionBiocompatible MaterialsPolymersBiomaterialsDirected evolutionSynthetic biologyTissue engineeringVirus particles

Identifiers

PMID24463066
PMCPMC3972820

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.