Evidence map›Paper›PMID 24462788›Full record

ReviewMechanisms of ageing and development

Healthy aging diets other than the Mediterranean: a focus on the Okinawan diet.

Donald Craig Willcox, Giovanni Scapagnini, Bradley J Willcox

Abstract readReview
In one paragraph

Review in Mechanisms of ageing and development. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 108 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
108citing papers in PubMed, 4 pooled it
15.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

108 citing papers in PubMed, 4 syntheses or guidelines pooled it, 260 citations in OpenAlex.

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  17. Blue Zone, a Demographic Concept and Beyond.American journal of lifestyle medicine · 2025
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48 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 3 countries.

Donald Craig WillcoxOkinawa International University, Department of Human Welfare, 2-6-1 Ginowan, Okinawa 901-2701, Japan; Department of Geriatric Medicine, University of Hawaii, HPM-9, 347 N. Kuakini Street, Honolulu, HI 96817, United States; Department of Research, Kuakini Medical Center, 347 N. Kuakini Street, Honolulu, HI 96817, United States. Electronic address: willcox@hawaii.edu.
Giovanni ScapagniniDepartment of Medicine and Health Science, University of Molise, Via de Sanctis, 86100 Campobasso, Italy.
Bradley J WillcoxDepartment of Geriatric Medicine, University of Hawaii, HPM-9, 347 N. Kuakini Street, Honolulu, HI 96817, United States; Department of Research, Kuakini Medical Center, 347 N. Kuakini Street, Honolulu, HI 96817, United States.
University of Hawaii System · USUniversity of Molise · IT

Funding

FOXO3 Genotype, InflammAging, Cardiovascular Disease, and Dementia. Kuakini Hawaii Lifespan Study III. Administrative Supplement.R01AG027060 · NIA · KUAKINI MEDICAL CENTER · PI Gregory J. Tranah, BRADLEY JOHN WILLCOX · 2005 to 2026
$8.1M
Energy-sensing Pathways, Healthy Aging and LongevityR01AG038707 · NIA · KUAKINI MEDICAL CENTER · PI WILLCOX, BRADLEY JOHN · 2011 to 2014
$1.4M
NIA NIH HHS R01 AG027060NIA NIH HHS R01 AG038707
6 · The paper itself

Abstract

The traditional diet in Okinawa is anchored by root vegetables (principally sweet potatoes), green and yellow vegetables, soybean-based foods, and medicinal plants. Marine foods, lean meats, fruit, medicinal garnishes and spices, tea, alcohol are also moderately consumed. Many characteristics of the traditional Okinawan diet are shared with other healthy dietary patterns, including the traditional Mediterranean diet, DASH diet, and Portfolio diet. All these dietary patterns are associated with reduced risk for cardiovascular disease, among other age-associated diseases. Overall, the important shared features of these healthy dietary patterns include: high intake of unrefined carbohydrates, moderate protein intake with emphasis on vegetables/legumes, fish, and lean meats as sources, and a healthy fat profile (higher in mono/polyunsaturated fats, lower in saturated fat; rich in omega-3). The healthy fat intake is likely one mechanism for reducing inflammation, optimizing cholesterol, and other risk factors. Additionally, the lower caloric density of plant-rich diets results in lower caloric intake with concomitant high intake of phytonutrients and antioxidants. Other shared features include low glycemic load, less inflammation and oxidative stress, and potential modulation of aging-related biological pathways. This may reduce risk for chronic age-associated diseases and promote healthy aging and longevity.

Indexed as

AgingDietBiomarkersCucurbitaceaeCurcumaDietary FatsDiet, MediterraneanDiet, WesternFeeding BehaviorFish ProductsFree Radical ScavengersFruitHumansInflammationInsulinJapanBiomarkersDietary FatsFree Radical ScavengersInsulinDASHDietHealthy agingLongevityOkinawaPortfolio

Identifiers

PMID24462788
PMCPMC5403516
OpenAlexW1991295722

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.