ReviewMolecular and cellular endocrinology2014
Premature menopause and risk of neurological disease: basic mechanisms and clinical implications.
Review in Molecular and cellular endocrinology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Management of Primary Ovarian Insufficiency Symptoms in Survivors of Childhood and Adolescent Cancer.Journal of the National Comprehensive Cancer Network : JNCCN · 2018Pooled it
- Multiple Sclerosis in Women: Impact of Different Life Stages on Treatment Decisions.CNS drugs · 2026Review
- Menopause age and type and dementia risk: a pooled analysis of 233 802 women.Age and ageing · 2024Article
- Article
- Age, Sex, Body Mass Index, Diet and Menopause Related Metabolites in a Large Homogeneous Alpine Cohort.Metabolites · 2022Article
- Knowledge of iatrogenic premature ovarian insufficiency among Chinese obstetricians and gynaecologists: a national questionnaire survey.Journal of ovarian research · 2020Article
- Estrogen Exerts Neuroprotective Effects in Vascular Dementia Rats by Suppressing Autophagy and Activating the Wnt/β-Catenin Signaling Pathway.Neurochemical research · 2020Article
- Changes in Inflammatory Response, Redox Status and NaNeurotoxicity research · 2020Article
- Is There Any MRI Pattern That Discriminates Female From Male Migraine Patients?Frontiers in neurology · 2019Review
- Sex differences in Alzheimer's disease and common neuropathologies of aging.Acta neuropathologica · 2018Article
- 17Oxidative medicine and cellular longevity · 2018Article
- Vitamin DNeuromolecular medicine · 2017Article
- Ovarian Conservation and Overall Survival in Young Women With Early-Stage Cervical Cancer.Obstetrics and gynecology · 2017Article
- Women's experiences of menopause in an online MS cohort: A case series.Multiple sclerosis and related disorders · 2016Article
- Update on primary ovarian insufficiency.Current opinion in endocrinology, diabetes, and obesity · 2015Review
- Infertility etiologies are genetically and clinically linked with other diseases in single meta-diseases.Reproductive biology and endocrinology : RB&E · 2015Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Since basic scientific studies in the 1990s revealed dramatic gender differences in neurological damage from cerebral ischemia, significant evidence has accumulated for a neuroprotective role of ovarian-derived 17β-Estradiol (E2). Intriguingly, observational studies have further suggested that early and prolonged loss of ovarian E2 (premature menopause) leads to a doubled lifetime risk for dementia and a fivefold increased risk of mortality from neurological disorders, but some controversy remains. Here, we briefly summarize and analyze clinical cohort studies assessing the detrimental neurological outcomes of premature menopause. Furthermore, we discuss current basic science studies elucidating the molecular mechanisms underlying the enhanced risk of neurological disease in prematurely menopausal women and the "window of opportunity" for estrogen benefit. Finally, we highlight four critical issues in the field that require collaboration between basic scientists and clinicians for successful resolution, with the ultimate goal of maintaining optimal neurological health in prematurely menopausal women.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.