Evidence map›Paper›PMID 24462720›Full record

ArticleNeurobiology of learning and memory2014

Reduced activity-dependent protein levels in a mouse model of the fragile X premutation.

Ramona E von Leden, Lindsey C Curley, Gian D Greenberg, Michael R Hunsaker, Rob Willemsen, Robert F Berman

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of learning and memory, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Ramona E von LedenDepartment of Neurological Surgery, School of Medicine, University of California, Davis, Davis, CA, USA.
Lindsey C CurleyDepartment of Neurological Surgery, School of Medicine, University of California, Davis, Davis, CA, USA.
Gian D GreenbergDepartment of Psychology, University of California, Davis, Davis, CA, USA.
Michael R HunsakerDepartment of Neurological Surgery, School of Medicine, University of California, Davis, Davis, CA, USA. Electronic address: mrhunsaker@icloud.com.
Rob WillemsenCBG-Department of Clinical Genetics, Erasmus MC, Rotterdam, The Netherlands; NeuroTherapeutic Research Institute, University of California, Davis, Davis, CA, USA.
Robert F BermanDepartment of Neurological Surgery, School of Medicine, University of California, Davis, Davis, CA, USA; NeuroTherapeutic Research Institute, University of California, Davis, Davis, CA, USA.
University of California, Davis · USErasmus MC · NLNeurological Surgery · US

Funding

UC DAVIS CLINICAL AND TRANSLATIONAL SCIENCE CENTER: BPCAUL1RR024146 · NCRR · UNIVERSITY OF CALIFORNIA AT DAVIS · PI BERGLUND, LARS F · 2006 to 2011
$27.0M
Mouse Models of FXTAS: Defining Critical Periods and Molecular TargetsRL1NS062411 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI BERMAN, ROBERT F · 2007 to 2011
$4.2M
Training Program in Basic NeuroscienceT32MH082174 · NIMH · UNIVERSITY OF CALIFORNIA AT DAVIS · PI W MARTIN USREY · 2007 to 2026
$3.1M
UC Davis Clinical and Translational Science CenterKL2RR024144 · NCRR · UNIVERSITY OF CALIFORNIA AT DAVIS · PI BERGLUND, LARS F · 2006 to 2011
$3.1M
Neuro Therapeutics Research Institute (1 of 6)UL1DE019583 · NIDCR · UNIVERSITY OF CALIFORNIA AT DAVIS · PI HAGERMAN, PAUL J · 2008 to 2011
$3.0M
Mouse Models to Define Critical Periods and Molecular Targets in FXTASR01NS079775 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI BERMAN, ROBERT F · 2013 to 2017
$1.7M
NCRR NIH HHS KL2 RR024144NCRR NIH HHS UL1 RR024146NIDCR NIH HHS UL1 DE019583NIMH NIH HHS T32 MH082174NIMH NIH HHS T32 MH 82174NINDS NIH HHS R01 NS079775NINDS NIH HHS RL1 NS062411
6 · The paper itself

Abstract

Environmental enrichment results in increased levels of Fmrp in brain and increased dendritic complexity. The present experiment evaluated activity-dependent increases in Fmrp levels in the motor cortex in response to training on a skilled forelimb reaching task in the CGG KI mouse model of the fragile X premutation. Fmrp, Arc, and c-Fos protein levels were quantified by Western blot in the contralateral motor cortex of mice following training to reach for sucrose pellets with a non-preferred paw and compared to levels in the ipsilateral motor cortex. After training, all mice showed increases in Fmrp, Arc, and c-Fos protein levels in the contralateral compared to the ipsilateral hemisphere; however, the increase in CGG KI mice was less than wildtype mice. Increases in Fmrp and Arc proteins scaled with learning, whereas this relationship was not observed with the c-Fos levels. These data suggest the possibility that reduced levels of activity-dependent proteins associated with synaptic plasticity such as Fmrp and Arc may contribute to the neurocognitive phenotype reported in the CGG KI mice and the fragile X premutation.

Indexed as

AnimalsDisease Models, AnimalFragile X Messenger Ribonucleoprotein 1Fragile X SyndromeGene Knock-In TechniquesMaleMiceMotor ActivityMotor CortexMutationFmr1 protein, mouseFragile X Messenger Ribonucleoprotein 1Arcc-FosCGG KI mouseEndophenotypeFmrpFragile X premutationWestern blot

Identifiers

PMID24462720
PMCPMC3966028
OpenAlexW2062372131

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.