ArticlePflugers Archiv : European journal of physiology1987
Currents carried by sodium ions through transient calcium channels in clonal GH3 pituitary cells.
Article in Pflugers Archiv : European journal of physiology, 1987. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 10 citations in OpenAlex.
- Na⁺Molecules (Basel, Switzerland) · 2017Review
- Thyrotropin-releasing hormone induces opposite effects on Ca2+ channel currents in pituitary cells by two pathways.Proceedings of the National Academy of Sciences of the United States of America · 1991Article
- Macroscopic and single-channel studies of two Ca2+ channel types in oocytes of the ascidian Ciona intestinalis.The Journal of membrane biology · 1990Article
- Calcium channels in cellular membranes.Journal of molecular neuroscience : MN · 1990Review
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The transient or T-type Ca channel currents of voltage-clamped clonal (GH3) pituitary cells were studied after blockade of Na and K channels. Removal of Ca ions from the bathing medium abolished the Ca currents and allowed Na ions to convey current through the transient channels. These Na currents (I Na,t) were activated at threshold potentials of ca. -85 mV, reached peak amplitudes (up to 2,000 pA) at -60 mV, and were 50% inactivated at holding membrane potentials of -110 to -120 mV. The time constant for inactivation of the maximal I Na,t was 12 +/- 2.4 msec (compared with 22.1 =/- 0.85 msec for maximal I Ca,t). The I Na,t was insensitive to tetrodotoxin (1 micron) and to nimodipine (200 nM) but was abolished by 100 micron external [Ca2+]. It is suggested that high affinity Ca binding sites in the channel modulate the ion selectivity and the current flow through T-type Ca channels.
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