ArticleAppetite2014
Associations of ghrelin with eating behaviors, stress, metabolic factors, and telomere length among overweight and obese women: preliminary evidence of attenuated ghrelin effects in obesity?
Article in Appetite, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 3 syntheses or guidelines pooled it, 69 citations in OpenAlex.
- Basal cortisol, cortisol reactivity, and telomere length: A systematic review and meta-analysis.Psychoneuroendocrinology · 2019Pooled it
- Diurnal cortisol slopes and mental and physical health outcomes: A systematic review and meta-analysis.Psychoneuroendocrinology · 2017Pooled it
- Perceived stress and telomere length: A systematic review, meta-analysis, and methodologic considerations for advancing the field.Brain, behavior, and immunity · 2016Pooled it
- Loneliness predicts postprandial ghrelin and hunger in women.Hormones and behavior · 2015Trial
- Interpersonal stressors predict ghrelin and leptin levels in women.Psychoneuroendocrinology · 2014Trial
- Subclinical inflammation in children with Down syndrome: implications for preventive care.Annals of pediatric endocrinology & metabolism · 2026Article
- Neurocognitive performance and appetite-regulating hormones in obesity with and without eating disorders: A comprehensive review and empirical analysis.Reviews in endocrine & metabolic disorders · 2026Review
- Food reward entrainment increases mealtime anxiety in goldfish via a ghrelin-dependent mechanism.Scientific reports · 2025Article
- Association between healthy neuroticism and eating behavior as revealed by the NKI Rockland Sample.Scientific reports · 2025Article
- Article
- Research progress on the role of mindfulness in intervention for adolescent obesity.Frontiers in endocrinology · 2024Review
- Phase-shifting the circadian glucocorticoid profile induces disordered feeding behaviour by dysregulating hypothalamic neuropeptide gene expression.Communications biology · 2023Article
- Are Peripheral Biomarkers Determinants of Eating Styles in Childhood and Adolescence Obesity? A Cross-Sectional Study.Nutrients · 2022Article
- Measurement of the influences of social processes in appetite using ecological momentary assessment.Appetite · 2021Article
- Mindfulness affects stress, ghrelin, and BMI of obese children: a clinical trial.Endocrine connections · 2020Article
- Down Syndrome Is a Metabolic Disease: Altered Insulin Signaling Mediates Peripheral and Brain Dysfunctions.Frontiers in neuroscience · 2020Review
- Article
- Threats to Belonging, Immune Function, and Eating Behavior: an Examination of Sex and Gender Differences.Current psychiatry reports · 2018Review
- Father Loss and Child Telomere Length.Pediatrics · 2017Article
- Control of Food Intake by Gastrointestinal Peptides: Mechanisms of Action and Possible Modulation in the Treatment of Obesity.Journal of neurogastroenterology and motility · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Ghrelin regulates homeostatic food intake, hedonic eating, and is a mediator in the stress response. In addition, ghrelin has metabolic, cardiovascular, and anti-aging effects. This cross-sectional study examined associations between total plasma ghrelin, caloric intake based on 3day diet diaries, hedonic eating attitudes, stress-related and metabolic factors, and leukocyte telomere length in overweight (n=25) and obese women (n=22). We hypothesized associations between total plasma ghrelin and eating behaviors, stress, metabolic, cardiovascular, and cell aging factors among overweight women, but not among obese women due to lower circulating ghrelin levels and/or central resistance to ghrelin. Confirming previous studies demonstrating lowered plasma ghrelin in obesity, ghrelin levels were lower in the obese compared with overweight women. Among the overweight, ghrelin was positively correlated with caloric intake, giving in to cravings for highly palatable foods, and a flatter diurnal cortisol slope across 3days. These relationships were non-significant among the obese group. Among overweight women, ghrelin was negatively correlated with insulin resistance, systolic blood pressure, and heart rate, and positively correlated with telomere length. Among the obese subjects, plasma ghrelin concentrations were negatively correlated with insulin resistance, but were not significantly correlated with blood pressure, heart rate or telomere length. Total plasma ghrelin and its associations with food intake, hedonic eating, and stress are decreased in obesity, providing evidence consistent with the theory that central resistance to ghrelin develops in obesity and ghrelin's function in appetite regulation may have evolved to prevent starvation in food scarcity rather than cope with modern food excess. Furthermore, ghrelin is associated with metabolic and cardiovascular health, and may have anti-aging effects, but these effects may be attenuated in obesity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.