Evidence map›Paper›PMID 24462453›Full record

ReviewAdvanced drug delivery reviews2014

Ultrasound-mediated blood-brain barrier disruption for targeted drug delivery in the central nervous system.

Muna Aryal, Costas D Arvanitis, Phillip M Alexander, Nathan McDannold

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Advanced drug delivery reviews, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 195 papers.

0numbers the graph read from it
0cells of the map it votes in
195citing papers in PubMed
20.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

195 citing papers in PubMed, 425 citations in OpenAlex.

  1. Localized blood-brain barrier opening in infiltrating gliomas with MRI-guided acoustic emissions-controlled focused ultrasound.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Trial
  2. Article
  3. Review
  4. Review
  5. Article
  6. Review
  7. Focused ultrasound for brain metastases.Neuro-oncology advances · 2026
    Review
  8. Review
  9. Review
  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Review
  16. Review
  17. Review
  18. Article
  19. Review
  20. Review

135 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Muna AryalDepartment of Physics, Boston College, Chestnut Hill, USA; Department of Radiology, Brigham & Women's Hospital, Harvard Medical School, Boston, USA.
Costas D ArvanitisDepartment of Radiology, Brigham & Women's Hospital, Harvard Medical School, Boston, USA.
Phillip M AlexanderDepartment of Radiology, Brigham & Women's Hospital, Harvard Medical School, Boston, USA; Institute of Biomedical Engineering, Department of Engineering Science, and Brasenose College, University of Oxford, Oxford, UK.
Nathan McDannoldDepartment of Radiology, Brigham & Women's Hospital, Harvard Medical School, Boston, USA. Electronic address: njm@bwh.harvard.edu.
Brigham and Women's Hospital · USBoston College · USHarvard University · US

Funding

Image Guided Therapy Center - Ultrasound-based sensor system for the monitoring of COVID-19 patientsP41EB015898 · NIBIB · BRIGHAM AND WOMEN'S HOSPITAL · PI TEMPANY, CLARE M · 2012 to 2021
$18.9M
IMAGE GUIDED THERAPY CENTERP41RR019703 · NCRR · BRIGHAM AND WOMEN'S HOSPITAL · PI JOLESZ, FERENC A · 2010 to 2011
$8.6M
Multidisciplinary Training in Image-Guided TherapyR25CA089017 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI FENNESSY, FIONA · 2001 to 2017
$7.8M
Ultrasound-induced blood-brain/tumor barrier disruption in brain metastasesP01CA174645 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI MCDANNOLD, NATHAN J., MCDANNOLD, NATHAN J. · 2013 to 2017
$6.2M
NCI NIH HHS P01 CA174645NCI NIH HHS R25 CA089017NCRR NIH HHS P41 RR019703NIBIB NIH HHS P41 EB015898
6 · The paper itself

Abstract

The physiology of the vasculature in the central nervous system (CNS), which includes the blood-brain barrier (BBB) and other factors, complicates the delivery of most drugs to the brain. Different methods have been used to bypass the BBB, but they have limitations such as being invasive, non-targeted or requiring the formulation of new drugs. Focused ultrasound (FUS), when combined with circulating microbubbles, is a noninvasive method to locally and transiently disrupt the BBB at discrete targets. This review provides insight on the current status of this unique drug delivery technique, experience in preclinical models, and potential for clinical translation. If translated to humans, this method would offer a flexible means to target therapeutics to desired points or volumes in the brain, and enable the whole arsenal of drugs in the CNS that are currently prevented by the BBB.

Indexed as

Drug Delivery SystemsAnimalsBlood-Brain BarrierHumansUltrasonicsUltrasonic TherapyBrainDrug deliveryMicrobubblesUltrasound

Identifiers

PMID24462453
PMCPMC4041837
OpenAlexW2067076937

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.