Trial reportInternational journal of radiation oncology, biology, physics2014
Emotional and behavioral functioning after conformal radiation therapy for pediatric ependymoma.
Trial report in International journal of radiation oncology, biology, physics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 35 citations in OpenAlex.
- The impact of socioeconomic status (SES) on cognitive outcomes following radiotherapy for pediatric brain tumors: a prospective, longitudinal trial.Neuro-oncology · 2021Trial
- Prospective longitudinal evaluation of emotional and behavioral functioning in pediatric patients with low-grade glioma treated with conformal radiation therapy.Journal of neuro-oncology · 2015Trial
- Supratentorial and Infratentorial Ependymoma.Advances and technical standards in neurosurgery · 2024Review
- Cognitive and Behavioral Outcome of Pediatric Low-Grade Central Nervous System Tumors Treated Only with Surgery: A Single Center Experience.Diagnostics (Basel, Switzerland) · 2023Article
- Article
- The rationale and development of a CyberKnife© registry for pediatric patients with CNS lesions.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2021Observational
- The Epidemiological Characteristics and Prognostic Factors of Low-Grade Brainstem Glioma: A Real-World Study of Pediatric and Adult Patients.Frontiers in oncology · 2020Article
- Survival and functional outcomes of molecularly defined childhood posterior fossa ependymoma: Cure at a cost.Cancer · 2019Article
- Trajectories of psychosocial and cognitive functioning in pediatric patients with brain tumors treated with radiation therapy.Neuro-oncology · 2019Article
- Brainstem Low-Grade Gliomas in Children-Excellent Outcomes With Multimodality Therapy.Journal of child neurology · 2017Article
- Biology and management of ependymomas.Neuro-oncology · 2016Review
- Social competence in pediatric brain tumor survivors: application of a model from social neuroscience and developmental psychology.Pediatric blood & cancer · 2015Review
- The potential utility of parent-reported attention screening in survivors of childhood cancer to identify those in need of comprehensive neuropsychological evaluation.Neuro-oncology practice · 2015Article
- The role of resection alone in select children with intracranial ependymoma: the Canadian Pediatric Brain Tumour Consortium experience.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2015Article
- Predictors of cognitive function in pediatric brain tumor patients: Pre-surgery through 24-month follow-up.Applied neuropsychology. ChildArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
purposeThe standard of care for pediatric patients with ependymoma involves postoperative radiation therapy. Prior research suggests that conformal radiation therapy (CRT) is associated with relative sparing of cognitive and academic functioning, but little is known about the effect of CRT on emotional and behavioral functioning. METHODS AND MATERIALS: A total of 113 patients with pediatric ependymoma underwent CRT using photons as part of their enrollment on an institutional trial. Patients completed annual evaluations of neurocognitive functioning during the first 5 years after CRT. Emotional and behavioral functioning was assessed via the Child Behavior Checklist.
resultsBefore CRT, emotional and behavioral functioning were commensurate with those of the normative population and within normal limits. After 5 years, means remained within normal limits but were significantly below the normative mean. Linear mixed models revealed a significant increase in attention problems over time. These problems were associated with age at diagnosis/CRT, tumor location, and extent of resection. A higher-than-expected incidence of school problems was present at all assessment points after baseline.
conclusionsThe use of photon CRT for ependymoma is associated with relatively stable emotional and behavioral functioning during the first 5 years after treatment. The exception is an increase in attention problems. Results suggest that intervening earlier in the survivorship period-during the first year posttreatment-may be beneficial.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.