Evidence map›Paper›PMID 24462370›Full record

Observational studyAmerican journal of human genetics2014

Causal effects of body mass index on cardiometabolic traits and events: a Mendelian randomization analysis.

Michael V Holmes, Leslie A Lange, Tom Palmer, Matthew B Lanktree, Kari E North, Berta Almoguera, Sarah Buxbaum, Hareesh R Chandrupatla, Clara C Elbers, Yiran Guo and 24 more

Erratum issuedOpen access · bronzeAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in American journal of human genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 129 papers, 17 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
129citing papers in PubMed, 17 pooled it
21.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

129 citing papers in PubMed, 17 syntheses or guidelines pooled it, 231 citations in OpenAlex.

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69 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

  • Erratum issued
5 · Who and what money

Authors and funding

34 authors at 20 institutions in 4 countries.

Michael V HolmesDivision of Transplantation, Department of Surgery, Perelman School of Medicine, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA; Genetic Epidemiology Group, Institute of Cardiovascular Science, Faculty of Population Health Sciences, University College London, 1-19 Torrington Place, London WC1E 6BT, UK. Electronic address: michael.holmes@uphs.upenn.edu.
Leslie A LangeDepartment of Genetics, University of North Carolina School of Medicine at Chapel Hill, Chapel Hill, NC 27514, USA.
Tom PalmerDivision of Health Sciences, Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK.
Matthew B LanktreeDepartment of Medicine, McMaster University, Hamilton, ON L8S 4L8, Canada.
Kari E NorthDepartment of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA.
Berta AlmogueraCenter for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Sarah BuxbaumJackson Heart Study Coordinating Center, Jackson State University, 350 West Woodrow Wilson Avenue, Suite 701, Jackson, MS 39213, USA.
Hareesh R ChandrupatlaCenter for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Clara C ElbersComplex Genetics Section, Department of Medical Genetics, University Medical Center Utrecht, 3584 CX Utrecht, the Netherlands.
Yiran GuoCenter for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Ron C HoogeveenDivision of Atherosclerosis & Vascular Medicine, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA.
Jin LiCenter for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Yun R LiCenter for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Daniel I SwerdlowGenetic Epidemiology Group, Institute of Cardiovascular Science, Faculty of Population Health Sciences, University College London, 1-19 Torrington Place, London WC1E 6BT, UK.
Mary CushmanDepartments of Medicine and Pathology, University of Vermont, 208 South Park Drive, Colchester, VT 05446 USA.
Tom S PriceThe Institute for Translational Medicine and Therapeutics, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Sean P CurtisMerck Research Laboratories, P.O. Box 2000, Rahway, NJ 07065, USA.
Myriam FornageThe University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Hakon HakonarsonCenter for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Sanjay R PatelDepartment of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
Susan RedlineDepartment of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
David S SiscovickCardiovascular Health Research Unit, Departments of Medicine and Epidemiology, University of Washington, Seattle, WA 98101, USA.
Michael Y TsaiDepartment of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55414, USA.
James G WilsonDepartment of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS 39216, USA.
Yvonne T van der SchouwJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, 3584 CX Utrecht, the Netherlands.
Garret A FitzGeraldThe Institute for Translational Medicine and Therapeutics, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Aroon D HingoraniGenetic Epidemiology Group, Institute of Cardiovascular Science, Faculty of Population Health Sciences, University College London, 1-19 Torrington Place, London WC1E 6BT, UK.
Juan P CasasGenetic Epidemiology Group, Institute of Cardiovascular Science, Faculty of Population Health Sciences, University College London, 1-19 Torrington Place, London WC1E 6BT, UK; Faculty of Epidemiology and Public Health, London School of Hygiene & Tropical Medicine, London WC1E 7HT, UK.
Paul I W de BakkerJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, 3584 CX Utrecht, the Netherlands; Brigham and Women's Hospital, 77 Avenue Louis Pasteur, New Research Building, Room 168, Boston, MA 02115, USA.
Stephen S RichCenter for Public Health Genomics, University of Virginia, Charlottesville, VA 22908, USA.
Eric E SchadtDepartment of Genomics, Mount Sinai School of Medicine, New York, NY 10029, USA.
Folkert W AsselbergsDivision of Heart and Lungs, Department of Cardiology, University Medical Centre Utrecht, Heidelberglaan 100, 3584 CX Utrecht, the Netherlands; Durrer Center for Cardiogenetic Research, ICIN - Netherlands Heart Institute, Catharijnesingel 52, Postbus 19258, 3501 DG Utrecht, the Netherlands; Faculty of Population Health Sciences, Institute of Cardiovascular Science, University College London, London WC1E 6BT, UK.
Alex P ReinerCenter for Public Health Genomics, University of Virginia, Charlottesville, VA 22908, USA; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Brendan J KeatingDivision of Transplantation, Department of Surgery, Perelman School of Medicine, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA; Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA. Electronic address: bkeating@mail.med.upenn.edu.
Children's Hospital of Philadelphia · USBrigham and Women's Hospital · USUniversity College London · GBUniversity Medical Center Utrecht · NLUniversity of North Carolina at Chapel Hill · USUniversity of Pennsylvania · USBaylor College of Medicine · USFred Hutch Cancer Center · USIcahn School of Medicine at Mount Sinai · USJackson State University · USMcMaster University · CAMerck & Co., Inc., Rahway, NJ, USA (United States) · USThe University of Texas Health Science Center at Houston · USTranslational Therapeutics (United States) · USUniversity of Minnesota · USUniversity of Mississippi Medical Center · USUniversity of Vermont · USUniversity of Virginia · USUniversity of Warwick · GBUniversity of Washington · US

Funding

Understanding Obesity In Relation to the Built EnvironmentP20MD006899 · NIMHD · JACKSON STATE UNIVERSITY · PI ADDISON, CLIFTON · 2012 to 2016
$5.3M
British Heart Foundation PG/09/022/26739Medical Research Council G0802432Medical Research Council MR/K006584/1NIMHD NIH HHS P20 MD006899
6 · The paper itself

Abstract

Elevated body mass index (BMI) associates with cardiometabolic traits on observational analysis, yet the underlying causal relationships remain unclear. We conducted Mendelian randomization analyses by using a genetic score (GS) comprising 14 BMI-associated SNPs from a recent discovery analysis to investigate the causal role of BMI in cardiometabolic traits and events. We used eight population-based cohorts, including 34,538 European-descent individuals (4,407 type 2 diabetes (T2D), 6,073 coronary heart disease (CHD), and 3,813 stroke cases). A 1 kg/m(2) genetically elevated BMI increased fasting glucose (0.18 mmol/l; 95% confidence interval (CI) = 0.12-0.24), fasting insulin (8.5%; 95% CI = 5.9-11.1), interleukin-6 (7.0%; 95% CI = 4.0-10.1), and systolic blood pressure (0.70 mmHg; 95% CI = 0.24-1.16) and reduced high-density lipoprotein cholesterol (-0.02 mmol/l; 95% CI = -0.03 to -0.01) and low-density lipoprotein cholesterol (LDL-C; -0.04 mmol/l; 95% CI = -0.07 to -0.01). Observational and causal estimates were directionally concordant, except for LDL-C. A 1 kg/m(2) genetically elevated BMI increased the odds of T2D (odds ratio [OR] = 1.27; 95% CI = 1.18-1.36) but did not alter risk of CHD (OR 1.01; 95% CI = 0.94-1.08) or stroke (OR = 1.03; 95% CI = 0.95-1.12). A meta-analysis incorporating published studies reporting 27,465 CHD events in 219,423 individuals yielded a pooled OR of 1.04 (95% CI = 0.97-1.12) per 1 kg/m(2) increase in BMI. In conclusion, we identified causal effects of BMI on several cardiometabolic traits; however, whether BMI causally impacts CHD risk requires further evidence.

Indexed as

Body Mass IndexMendelian Randomization AnalysisAdolescentAdultAgedAged, 80 and overBlood GlucoseBlood PressureCholesterol, HDLCholesterol, LDLCoronary DiseaseDiabetes Mellitus, Type 2FastingFemaleGenetic Association StudiesHumansBlood GlucoseCholesterol, HDLCholesterol, LDLInsulinInterleukin-6

Identifiers

PMID24462370
PMCPMC3928659
OpenAlexW2005648153

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.