Evidence map›Paper›PMID 24461761›Full record

ReviewThe Lancet. Respiratory medicine2013

Diet and asthma: vitamins and methyl donors.

Yueh-Ying Han, Josh Blatter, John M Brehm, Erick Forno, Augusto A Litonjua, Juan C Celedón

Open access · bronzeAbstract readReview
In one paragraph

Review in The Lancet. Respiratory medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 58 citations in OpenAlex.

  1. Trial
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. The Role of Vitamins in the Pathogenesis of Asthma.International journal of molecular sciences · 2023
    Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Diet and asthma: Is the sum more important than the parts?The Journal of allergy and clinical immunology · 2021
    Article
  15. Review
  16. Prospects for Use of Single-Cell Sequencing to Assess DNA Methylation in Asthma.Medical science monitor : international medical journal of experimental and clinical research · 2020
    Review
  17. Article
  18. Article
  19. Diet, Lung Function, and Asthma Exacerbations in Puerto Rican Children.Pediatric allergy, immunology, and pulmonology · 2017
    Article
  20. Dietary intake is associated with respiratory health outcomes and DNA methylation in children with asthma.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Yueh-Ying HanDivision of Pediatric Pulmonary Medicine, Allergy, and Immunology, Children's Hospital of Pittsburgh of UPMC, Department of Pediatrics, University of Pittsburgh, Pittsburgh, PA, USA.
Josh BlatterDivision of Pediatric Pulmonary Medicine, Allergy, and Immunology, Children's Hospital of Pittsburgh of UPMC, Department of Pediatrics, University of Pittsburgh, Pittsburgh, PA, USA.
John M BrehmDivision of Pediatric Pulmonary Medicine, Allergy, and Immunology, Children's Hospital of Pittsburgh of UPMC, Department of Pediatrics, University of Pittsburgh, Pittsburgh, PA, USA.
Erick FornoDivision of Pediatric Pulmonary Medicine, Allergy, and Immunology, Children's Hospital of Pittsburgh of UPMC, Department of Pediatrics, University of Pittsburgh, Pittsburgh, PA, USA.
Augusto A LitonjuaChanning Division of Network Medicine and Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Juan C CeledónDivision of Pediatric Pulmonary Medicine, Allergy, and Immunology, Children's Hospital of Pittsburgh of UPMC, Department of Pediatrics, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address: juan.celedon@chp.edu.
Children's Hospital of Pittsburgh · USUniversity of Pittsburgh · USBrigham and Women's Hospital · US

Funding

Epigenetic Variation and Childhood Asthma in Puerto RicansR01HL117191 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CELEDON, JUAN CARLOS · 2013 to 2020
$5.8M
Genes, Home Allergens and Asthma Puerto Rican ChildrenR01HL079966 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CELEDON, JUAN CARLOS · 2006 to 2010
$3.8M
NHLBI NIH HHS HL079966NHLBI NIH HHS R01 HL079966NHLBI NIH HHS R01 HL117191
6 · The paper itself

Abstract

Diet changes can partly explain the high burden of asthma in industrialised nations. Findings from experimental studies have stimulated many observational studies of the association between vitamins (A, C, D, and E) or nutrients acting as methyl donors (folate, vitamin B12, and choline) and asthma. However, observational studies are susceptible to several sources of bias; well conducted randomised controlled trials (RCTs) are the gold standard to establish whether diet has an effect on asthma. Evidence from observational studies and a few RCTs strongly justifies ongoing and future RCTs in three areas: vitamin D for the prevention or treatment of asthma, choline supplementation as adjuvant treatment for asthma, and vitamin E to prevent the detrimental effects of air pollution in patients with asthma. At present, insufficient evidence exists to recommend supplementation with any vitamin or nutrient acting as a methyl donor to prevent or treat asthma.

Indexed as

DietAntioxidantsAsthmaHumansPrognosisVitaminsAntioxidantsVitamins

Identifiers

PMID24461761
PMCPMC3904132
OpenAlexW2161881807

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.