ArticleThe Lancet. Respiratory medicine2013
Serum concentrations of club cell secretory protein (Clara) and cancer mortality in adults: a population-based, prospective cohort study.
Article in The Lancet. Respiratory medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Multiple criteria optimization joint analyses of microarray experiments in lung cancer: from existing microarray data to new knowledge.Cancer medicine · 2015Pooled it
- Short halt in vaping modifies cardiorespiratory parameters and urine metabolome: a randomized trial.American journal of physiology. Lung cellular and molecular physiology · 2020Trial
- Impaired CC16-mediated host responses to rhinovirus in nasal epithelial cells from patients with asthma.The Journal of allergy and clinical immunology · 2026Article
- Nomogram model using serum Club cell secretory protein 16 to predict prognosis and acute exacerbation in patients with idiopathic pulmonary fibrosis.European journal of medical research · 2025Article
- Cobalt exposure and pulmonary function reduction in chronic obstructive pulmonary disease patients: the mediating role of club cell secretory protein.Respiratory research · 2024Article
- txci-ATAC-seq: a massive-scale single-cell technique to profile chromatin accessibility.Genome biology · 2024Article
- Low CC16 mRNA Expression Levels in Bronchial Epithelial Cells Are Associated with Asthma Severity.American journal of respiratory and critical care medicine · 2023Article
- Associations of Serum Clara Cell Protein 16 with Severity and Prognosis in Adults with Community-Acquired Pneumonia.International journal of general medicine · 2023Article
- Lung developmental is altered after inhalation exposure to various concentrations of calcium arsenate.Toxicology and applied pharmacology · 2021Article
- Cellular and functional heterogeneity of the airway epithelium.Mucosal immunology · 2021Review
- Development of a multiplex mass spectrometry method for simultaneous quantification of urinary proteins related to respiratory health.Scientific reports · 2021Article
- Club cell protein 16 in sera from trauma patients modulates neutrophil migration and functionality via CXCR1 and CXCR2.Molecular medicine (Cambridge, Mass.) · 2019Article
- CC16 Levels into Adult Life Are Associated with Nitrogen Dioxide Exposure at Birth.American journal of respiratory and critical care medicine · 2019Article
- Club Cell Secretory Protein Deficiency Leads to Altered Lung Function.American journal of respiratory and critical care medicine · 2019Article
- Roles of Thyroid Transcription Factor 1 in Lung Cancer Biology.Vitamins and hormones · 2018Review
- Response to García-Nieto et al. Comments on Beamer et al. Association of Children's Urinary CC16 Levels with Arsenic Concentrations in Multiple Environmental Media. Int. J. Environ. Res. Public Health 2016, 13, 521.International journal of environmental research and public health · 2016Article
- Club Cell Protein 16 (CC16) Augmentation: A Potential Disease-modifying Approach for Chronic Obstructive Pulmonary Disease (COPD).Expert opinion on therapeutic targets · 2016Review
- Association of Children's Urinary CC16 Levels with Arsenic Concentrations in Multiple Environmental Media.International journal of environmental research and public health · 2016Article
- The role and importance of club cells (Clara cells) in the pathogenesis of some respiratory diseases.Kardiochirurgia i torakochirurgia polska = Polish journal of cardio-thoracic surgery · 2016Article
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5 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundClub cell secretory protein (Clara) (CC16) is produced mainly by bronchiolar club cells and has been shown to have protective effects against airway inflammation and oxidative stress from cigarette smoking and related carcinogens. The goal of this study was to establish whether serum CC16 concentrations predict all-cause and cancer-specific mortality in adults.
methodsWe used data from the population-based Tucson Epidemiological Study of Airway Obstructive Diseases (TESAOD), a prospective cohort study of respiratory health initiated in Tucson, AZ, USA, in 1972, that recruited a multistage stratified cluster sample of non-Hispanic white households. We measured serum CC16 concentrations in cryopreserved serum samples and reviewed vital status up to Jan 1, 2011, through contact with next of kin, collection of death certificates, and searches of the National Death Index. Our primary analysis was the relation of baseline serum CC16 to all-cause mortality or cause-specific mortality risk, analysed by adjusted Cox proportional hazards models.
findings1086 TESAOD participants aged 21-70 years at enrolment were eligible for inclusion. Of these, 653 (60%) had died by 2011, and cause of death was ascertained for 649 (99%). When adjusted for sex, age, education, body-mass index, smoking and pack-years, and baseline levels of lung function, serum CC16 concentrations at baseline were inversely associated with mortality risk over the study follow-up. Mortality risk increased for each 1-SD decrease in CC16 (adjusted hazard ratio [HR] 1·16 [95% CI 1·06-1·26]; p=0·0007). For cause-specific mortality, each 1-SD decrease in serum CC16 was associated with an increased risk of dying of cancer (adjusted HR 1·41 [1·19-1·67]; p<0·0001). In the subset of smokers, the corresponding adjusted HR for mortality by lung cancer was 1·52 (1·14-2·03; p=0·004).
interpretationSerum CC16 concentrations can predict mortality risk in the general adult population. The excess risk associated with lower CC16 concentrations is predominantly driven by cancer, particularly lung cancer.
fundingNational Heart, Lung, and Blood Institute.
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