Evidence map›Paper›PMID 24461715›Full record

ArticleLancet (London, England)2014

Acute myocardial infarction: a comparison of short-term survival in national outcome registries in Sweden and the UK.

Sheng-Chia Chung, Rolf Gedeborg, Owen Nicholas, Stefan James, Anders Jeppsson, Charles Wolfe, Peter Heuschmann, Lars Wallentin, John Deanfield, Adam Timmis and 2 more

Registry-linked trialAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Lancet (London, England), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01359033 (Compare the Patient Risk and Between-hospital Variation in Myocardial Infarction Mortality in the United Kingdom and Sweden), which is not on this map. Cited by 121 papers.

0numbers the graph read from it
0cells of the map it votes in
121citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01359033 completednot on this map

Compare the Patient Risk and Between-hospital Variation in Myocardial Infarction Mortality in the United Kingdom and Sweden

TypeobservationalSponsorUniversity College, LondonRan2011 to 2014Enrolled510,863ConditionsAcute Myocardial Infarction
3 · Its place in the literature

Who cites it

121 citing papers in PubMed.

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  11. OECD indicator 'AMI 30-day mortality' is neither comparable between countries nor suitable as indicator for quality of acute care.Clinical research in cardiology : official journal of the German Cardiac Society · 2024
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  16. Now is the time to consider reducing the total ischemic time.The Korean journal of internal medicine · 2024
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  17. The everolimus eluting Synergy MegatronCatheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions · 2023
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61 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Sheng-Chia ChungFarr Institute of Health Informatics Research at UCL Partners, University College London, London, UK.
Rolf GedeborgUppsala Clinical Research Centre, Uppsala University, Uppsala, Sweden.
Owen NicholasNational Institute for Clinical Outcomes Research, University College London, London, UK.
Stefan JamesUppsala Clinical Research Centre, Uppsala University, Uppsala, Sweden; Department of Medical Sciences, Cardiology, Uppsala University, Uppsala, Sweden.
Anders JeppssonDepartment of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Department of Cardiothoracic Surgery, Sahlgrenska University Hospital, Gothenburg, Sweden.
Charles WolfeDivision of Health and Social Care Research, King's College London, London, UK; National Institute of Health Research Comprehensive Biomedical Research Centre, Guy's & St Thomas' NHS Foundation Trust and King's College London, London, UK.
Peter HeuschmannInstitute for Clinical Epidemiology and Biometry and Comprehensive Heart Failure Centre, University of Würzburg, Würzburg, Germany.
Lars WallentinUppsala Clinical Research Centre, Uppsala University, Uppsala, Sweden; Department of Medical Sciences, Cardiology, Uppsala University, Uppsala, Sweden.
John DeanfieldCentre for Cardiovascular Prevention and Outcomes, University College London, London, UK.
Adam TimmisNational Institute for Health Research, Biomedical Research Unit, Bart's Health London, London, UK.
Tomas JernbergDepartment of Medicine, Huddinge, Section of Cardiology, Karolinska Institute, Stockholm, Sweden. Electronic address: tomas.jernberg@karolinska.se.
Harry HemingwayFarr Institute of Health Informatics Research at UCL Partners, University College London, London, UK. Electronic address: h.hemingway@ucl.ac.uk.

Funding

Arthritis Research UKBritish Heart FoundationCancer Research UKChief Scientist OfficeDepartment of Health RP-PG-0407-10184Department of Health RP-PG-0407-10314Medical Research Council G0902393/99558Medical Research Council MR/K006584/1Wellcome TrustWellcome Trust 086091/Z/08/Z
6 · The paper itself

Abstract

backgroundInternational research for acute myocardial infarction lacks comparisons of whole health systems. We assessed time trends for care and outcomes in Sweden and the UK.

methodsWe used data from national registries on consecutive patients registered between 2004 and 2010 in all hospitals providing care for acute coronary syndrome in Sweden and the UK. The primary outcome was all-cause mortality 30 days after admission. We compared effectiveness of treatment by indirect casemix standardisation. This study is registered with ClinicalTrials.gov, number NCT01359033.

findingsWe assessed data for 119,786 patients in Sweden and 391,077 in the UK. 30-day mortality was 7·6% (95% CI 7·4-7·7) in Sweden and 10·5% (10·4-10·6) in the UK. Mortality was higher in the UK in clinically relevant subgroups defined by troponin concentration, ST-segment elevation, age, sex, heart rate, systolic blood pressure, diabetes mellitus status, and smoking status. In Sweden, compared with the UK, there was earlier and more extensive uptake of primary percutaneous coronary intervention (59% vs 22%) and more frequent use of β blockers at discharge (89% vs 78%). After casemix standardisation the 30-day mortality ratio for UK versus Sweden was 1·37 (95% CI 1·30-1·45), which corresponds to 11,263 (95% CI 9620-12,827) excess deaths, but did decline over time (from 1·47, 95% CI 1·38-1·58 in 2004 to 1·20, 1·12-1·29 in 2010; p=0·01).

interpretationWe found clinically important differences between countries in acute myocardial infarction care and outcomes. International comparisons research might help to improve health systems and prevent deaths.

fundingSeventh Framework Programme for Research, National Institute for Health Research, Wellcome Trust (UK), Swedish Association of Local Authorities and Regions, Swedish Heart-Lung Foundation.

Indexed as

AgedFemaleHumansMaleMyocardial InfarctionRegistriesRisk FactorsSurvival AnalysisSwedenUnited Kingdom

Identifiers

PMID24461715
PMCPMC4255068

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.