Evidence map›Paper›PMID 24461628›Full record

ReviewOral oncology2014

Epidemiology of HPV-associated oropharyngeal cancer.

Kristen B Pytynia, Kristina R Dahlstrom, Erich M Sturgis

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Oral oncology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05477992 (Haemorrhage Risk Reduction Using Endovascular Embolisation in Place of Vessel Ligation for Patients Undergoing Transoral Robotic Surgery), which is not on this map. Cited by 209 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
209citing papers in PubMed, 7 pooled it
31.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05477992 naunknown statusnot on this mapstarted 2022, after this paper: background citation

Haemorrhage Risk Reduction Using Endovascular Embolisation in Place of Vessel Ligation for Patients Undergoing Transoral Robotic Surgery (HELPR)

TypeinterventionalSponsorRoyal Marsden NHS Foundation TrustRan2022 to 2023Enrolled10ConditionsHead and Neck CancerArmsEndovascular embolization
3 · Its place in the literature

Who cites it

209 citing papers in PubMed, 7 syntheses or guidelines pooled it, 535 citations in OpenAlex.

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  5. The effects of zinc on radiation-induced dysgeusia: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2020
    Pooled it
  6. Diagnosis and referral delays in primary care for oral squamous cell cancer: a systematic review.The British journal of general practice : the journal of the Royal College of General Practitioners · 2019
    Pooled it
  7. Pooled it
  8. Early HPV ctDNA Kinetics and Imaging Biomarkers Predict Therapeutic Response in p16+ Oropharyngeal Squamous Cell Carcinoma.Clinical cancer research : an official journal of the American Association for Cancer Research · 2022
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149 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Kristen B PytyniaDepartment of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, United States. Electronic address: KBPytynia@mdanderson.org.
Kristina R DahlstromDepartment of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
Erich M SturgisDepartment of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, United States; Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
The University of Texas MD Anderson Cancer Center · US

Funding

R25 SUPPLEMENT IN GENETIC EPIDEMIOLOGY EDUCATIONR25CA057730 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI CHANG, SHINE · 1992 to 2016
$18.6M
NCI NIH HHS R25 CA057730
6 · The paper itself

Abstract

Squamous cell carcinoma of the oropharynx is increasing in incidence in epidemic proportion. This site specific increase in incidence is due to an increase in human papillomavirus (HPV)-related squamous cell carcinoma, while the incidence of tobacco related squamous cell carcinoma is decreasing. In particular, the incidence of HPV-related oropharyngeal squamous cell carcinoma (OPSCC) is increased among middle aged white men, and sexual behavior is a risk factor. HPV-related oropharyngeal squamous cell carcinoma represents a growing etiologically distinct subset of head and neck cancers with unique epidemiological, clinical, and molecular characteristics that differ from those of HPV-unassociated cancers. In this review, we discuss the epidemiology of HPV-related OPSCC, the prevalence of oral/oropharyngeal HPV infection, and efforts aimed at reducing the incidence of HPV-related OPSCC.

Indexed as

HumansOropharyngeal NeoplasmsPapillomavirus InfectionsPrevalenceRisk FactorsEpidemiologyHuman papillomavirusOropharyngeal cancer

Identifiers

PMID24461628
PMCPMC4444216
OpenAlexW2093292614

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.